In this review, we outline the application and contribution of transgenic technology to
establishing the genetic basis of blood pressure regulation and its dysfunction. Apart from a …

Human essential hypertension is a complex, multifactorial, quantitative trait under a
polygenic control. Several strategies have been developed over the last decade to dissect …

Mitochondria are a major site of reactive oxygen species production, which may contribute to
the development of cardiovascular disease. Protecting mitochondria from oxidative damage …

Genetically modified mice are mainstream tools for medical research. The background
strains used to generate transgenic and knockout mice have been studied extensively. In …

A consomic rat strain is one in which an entire chromosome is introgressed into the isogenic
background of another inbred strain using marker assisted selection. The development and …

Essential hypertension affects 20 to 30% of the population worldwide and contributes
significantly to cardiovascular mortality and morbidity. Heridability of blood pressure is …

Objective: Mitochondria-derived reactive oxygen species (ROS) play important roles in the
development of cardiovascular disease highlighting the need for novel targeted therapies …

Human essential hypertension is a complex polygenic trait with underlying genetic
components that remain unknown. The stroke-prone spontaneously hypertensive rat …

Thee present study analysed the quantification of rutin in raw buckwheat extract (RBE) and
germinated buckwheat extract (GBE) by high performance liquid chromatography (HPLC) …

The seventh iteration of the reference genome assembly for Rattus norvegicus—mRatBN7.
2—corrects numerous misplaced segments and reduces base-level errors by approximately …