All the tau we cannot see
B Hyman - Annual Review of Medicine, 2023 - annualreviews.org
Alzheimer's disease (AD) was described in 1906 as a dementing disease marked by the
presence of two types of fibrillar aggregates in the brain: neurofibrillary tangles and senile …
presence of two types of fibrillar aggregates in the brain: neurofibrillary tangles and senile …
Assembly of recombinant tau into filaments identical to those of Alzheimer's disease and chronic traumatic encephalopathy
Abundant filamentous inclusions of tau are characteristic of more than 20
neurodegenerative diseases that are collectively termed tauopathies. Electron cryo …
neurodegenerative diseases that are collectively termed tauopathies. Electron cryo …
Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases
Misfolding and aggregation of disease-specific proteins, resulting in the formation of
filamentous cellular inclusions, is a hallmark of neurodegenerative disease with …
filamentous cellular inclusions, is a hallmark of neurodegenerative disease with …
Novel aspects of the phosphorylation and structure of pathological tau: implications for tauopathy biomarkers
T Kimura, H Sato, M Kano, L Tatsumi… - FEBS Open bio, 2024 - Wiley Online Library
The deposition of highly phosphorylated and aggregated tau is a characteristic of
tauopathies, including Alzheimer's disease. It has long been known that different isoforms of …
tauopathies, including Alzheimer's disease. It has long been known that different isoforms of …
Unified epigenomic, transcriptomic, proteomic, and metabolomic taxonomy of Alzheimer's disease progression and heterogeneity
Alzheimer's disease (AD) is a heterogeneous disorder with abnormalities in multiple
biological domains. In an advanced machine learning analysis of postmortem brain and in …
biological domains. In an advanced machine learning analysis of postmortem brain and in …
Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment
C Danis, E Dupré, O Zejneli, R Caillierez, A Arrial… - Molecular Therapy, 2022 - cell.com
Tau proteins aggregate into filaments in brain cells in Alzheimer's disease and related
disorders referred to as tauopathies. Here, we used fragments of camelid heavy-chain-only …
disorders referred to as tauopathies. Here, we used fragments of camelid heavy-chain-only …
Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer's disease brain
B Frey, D Holzinger, K Taylor, DE Ehrnhoefer… - Acta Neuropathologica …, 2023 - Springer
Tau seed amplification assays (SAAs) directly measure the seeding activity of tau and would
therefore be ideal biomarkers for clinical trials targeting seeding-competent tau in …
therefore be ideal biomarkers for clinical trials targeting seeding-competent tau in …
Specific detection of tau seeding activity in Alzheimer's disease using rationally designed biosensor cells
A Lathuiliere, Y Jo, R Perbet, C Donahue… - Molecular …, 2023 - Springer
Background The prion-like propagation of tau in neurodegenerative disorders implies that
misfolded pathological tau can recruit the normal protein and template its aggregation. Here …
misfolded pathological tau can recruit the normal protein and template its aggregation. Here …
Self‐Aggregating Tau Fragments Recapitulate Pathologic Phenotypes and Neurotoxicity of Alzheimer's Disease in Mice
In tauopathy conditions, such as Alzheimer's disease (AD), highly soluble and natively
unfolded tau polymerizes into an insoluble filament; however, the mechanistic details of this …
unfolded tau polymerizes into an insoluble filament; however, the mechanistic details of this …
Pick's disease, seeding an answer to the clinical diagnosis conundrum
Pick's disease (PiD) is a devastating neurodegenerative disease that is characterized by
dementia, frontotemporal lobar degeneration, and the aggregation of 3R tau in …
dementia, frontotemporal lobar degeneration, and the aggregation of 3R tau in …