The role of the haematopoietic stem cell niche in development and ageing
TL Cain, M Derecka… - Nature Reviews Molecular …, 2024 - nature.com
Blood production depends on rare haematopoietic stem cells (HSCs) and haematopoietic
stem and progenitor cells (HSPCs) that ultimately take up residence in the bone marrow …
stem and progenitor cells (HSPCs) that ultimately take up residence in the bone marrow …
Early hematopoiesis and macrophage development
KE McGrath, JM Frame, J Palis - Seminars in immunology, 2015 - Elsevier
The paradigm that all blood cells are derived from hematopoietic stem cells (HSCs) has
been challenged by two findings. First, there are tissue-resident hematopoietic cells …
been challenged by two findings. First, there are tissue-resident hematopoietic cells …
Mapping human haematopoietic stem cells from haemogenic endothelium to birth
The ontogeny of human haematopoietic stem cells (HSCs) is poorly defined owing to the
inability to identify HSCs as they emerge and mature at different haematopoietic sites. Here …
inability to identify HSCs as they emerge and mature at different haematopoietic sites. Here …
Lifelong multilineage contribution by embryonic-born blood progenitors
Haematopoietic stem cells (HSCs) arise in the embryo from the arterial endothelium through
a process known as the endothelial-to-haematopoietic transition (EHT),,–. This process …
a process known as the endothelial-to-haematopoietic transition (EHT),,–. This process …
Murine foetal liver supports limited detectable expansion of life-long haematopoietic progenitors
Current dogma asserts that the foetal liver (FL) is an expansion niche for recently specified
haematopoietic stem cells (HSCs) during ontogeny. Indeed, between embryonic day of …
haematopoietic stem cells (HSCs) during ontogeny. Indeed, between embryonic day of …
GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1
R Thambyrajah, M Mazan, R Patel, V Moignard… - Nature cell …, 2016 - nature.com
In vertebrates, the first haematopoietic stem cells (HSCs) with multi-lineage and long-term
repopulating potential arise in the AGM (aorta–gonad–mesonephros) region. These HSCs …
repopulating potential arise in the AGM (aorta–gonad–mesonephros) region. These HSCs …
Embryonic endothelial evolution towards first hematopoietic stem cells revealed by single-cell transcriptomic and functional analyses
Hematopoietic stem cells (HSCs) in adults are believed to be born from hemogenic
endothelial cells (HECs) in mid-gestational embryos. Due to the rare and transient nature …
endothelial cells (HECs) in mid-gestational embryos. Due to the rare and transient nature …
Single-cell transcriptomics reveal the dynamic of haematopoietic stem cell production in the aorta
Haematopoietic stem cells (HSCs) are generated from haemogenic endothelial (HE) cells
via the formation of intra-aortic haematopoietic clusters (IAHCs) in vertebrate embryos. The …
via the formation of intra-aortic haematopoietic clusters (IAHCs) in vertebrate embryos. The …
Murine AGM single-cell profiling identifies a continuum of hemogenic endothelium differentiation marked by ACE
In vitro generation and expansion of hematopoietic stem cells (HSCs) holds great promise
for the treatment of any ailment that relies on bone marrow or blood transplantation. To …
for the treatment of any ailment that relies on bone marrow or blood transplantation. To …
Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition
CO Lizama, JS Hawkins, CE Schmitt, FL Bos… - Nature …, 2015 - nature.com
Abstract Changes in cell fate and identity are essential for endothelial-to-haematopoietic
transition (EHT), an embryonic process that generates the first adult populations of …
transition (EHT), an embryonic process that generates the first adult populations of …