Probiotics, prebiotics and synbiotics: Safe options for next-generation therapeutics

MK Yadav, I Kumari, B Singh, KK Sharma… - Applied microbiology and …, 2022 - Springer
Probiotics have been considered as an economical and safe alternative for the treatment of
a large number of chronic diseases and improvement of human health. They are known to …

Anti-inflammatory and immunomodulatory effects of probiotics in gut inflammation: a door to the body

F Cristofori, VN Dargenio, C Dargenio… - Frontiers in …, 2021 - frontiersin.org
Hosting millions of microorganisms, the digestive tract is the primary and most important part
of bacterial colonization. On one side, in cases of opportunistic invasion, the abundant …

The clinical evidence for postbiotics as microbial therapeutics

A Mosca, AT Abreu Y Abreu, KA Gwee, G Ianiro… - Gut …, 2022 - Taylor & Francis
An optimally operating microbiome supports protective, metabolic, and immune functions,
but disruptions produce metabolites and toxins which can be involved in many conditions …

The human milk microbiota: origin and potential roles in health and disease

L Fernández, S Langa, V Martín, A Maldonado… - Pharmacological …, 2013 - Elsevier
Human milk has been traditionally considered sterile; however, recent studies have shown
that it represents a continuous supply of commensal, mutualistic and/or potentially probiotic …

Unravelling the effects of the environment and host genotype on the gut microbiome

A Spor, O Koren, R Ley - Nature Reviews Microbiology, 2011 - nature.com
To what extent do host genetics control the composition of the gut microbiome? Studies
comparing the gut microbiota in human twins and across inbred mouse lines have yielded …

Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology

H Hardy, J Harris, E Lyon, J Beal, AD Foey - Nutrients, 2013 - mdpi.com
Probiotics are beneficial microbes that confer a realistic health benefit on the host, which in
combination with prebiotics,(indigestible dietary fibre/carbohydrate), also confer a health …

Emerging molecular insights into the interaction between probiotics and the host intestinal mucosa

PA Bron, P Van Baarlen, M Kleerebezem - Nature Reviews …, 2012 - nature.com
Probiotic bacteria can modulate immune responses in the host gastrointestinal tract to
promote health. The genomics era has provided novel opportunities for the discovery and …

Genes and molecules of lactobacilli supporting probiotic action

S Lebeer, J Vanderleyden… - … and Molecular Biology …, 2008 - Am Soc Microbiol
Lactobacilli have been crucial for the production of fermented products for centuries. They
are also members of the mutualistic microbiota present in the human gastrointestinal and …

Modulation of pulmonary microbiota by antibiotic or probiotic aerosol therapy: a strategy to promote immunosurveillance against lung metastases

V Le Noci, S Guglielmetti, S Arioli, C Camisaschi… - Cell reports, 2018 - cell.com
Pulmonary immunological tolerance to inhaled particulates might create a permissive milieu
for lung metastasis. Lung microbiota contribute to pulmonary tolerance; here, we explored …

Mechanisms of action of probiotics: recent advances

SC Ng, AL Hart, MA Kamm, AJ Stagg… - Inflammatory bowel …, 2009 - academic.oup.com
The intestinal microbiota plays a fundamental role in maintaining immune homeostasis. In
controlled clinical trials probiotic bacteria have demonstrated a benefit in treating …