Heterogeneity of memory T cells in aging

A Jain, I Sturmlechner, CM Weyand… - Frontiers in …, 2023 - frontiersin.org
Immune memory is a requisite and remarkable property of the immune system and is the
biological foundation of the success of vaccinations in reducing morbidity from infectious …

Global Analysis of a Fractional‐Order Hepatitis B Virus Model Under Immune Response in the Presence of Cytokines

PA Naik, BM Yeolekar, S Qureshi… - Advanced Theory …, 2024 - Wiley Online Library
This research proposes and investigates an epidemiological model to study the dynamic
behaviors of the Hepatitis B virus (HBV) under immune response and cytokine influence …

Modeling and analysis of the fractional-order epidemic model to investigate mutual influence in HIV/HCV co-infection

PA Naik, BM Yeolekar, S Qureshi, M Yeolekar… - Nonlinear …, 2024 - Springer
Based on the Caputo fractional-order derivative, this work investigates the dynamics of a
newly developed co-infection model of Human immunodeficiency virus (HIV) and Hepatitis …

Modeling of psoriasis by considering drug influence: A mathematical approach with memory trace

F Özköse - Computers in Biology and Medicine, 2024 - Elsevier
Psoriasis is an immune-mediated genetic disease, characterized by its manifestation on the
skin, the joints, or both. In this paper, our primary aim is to increase awareness about the …

Reversal of T-cell exhaustion: Mechanisms and synergistic approaches

Y Hu, Y Zhang, F Shi, R Yang, J Yan, T Han… - International …, 2024 - Elsevier
T cells suffer from long-term antigen stimulation and insufficient energy supply, leading to a
decline in their effector functions, memory capabilities, and proliferative capacity, ultimately …

Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity

S Pei, X Deng, R Yang, H Wang, JH Shi, X Wang… - Nature Aging, 2024 - nature.com
Aging compromises antitumor immunity, but the underlying mechanisms remain elusive.
Here, we report that aging impairs the generation of CD8+ tissue resident memory T (TRM) …

[HTML][HTML] PREX1 improves homeostatic proliferation to maintain a naive CD4+ T cell compartment in older age

H Zhang, H Okuyama, A Jain, RR Jadhav, B Wu… - JCI insight, 2024 - ncbi.nlm.nih.gov
The human adult immune system maintains normal T cell counts and compensates for T cell
loss throughout life, mainly through peripheral homeostatic proliferation after the ability of …

[PDF][PDF] Age-Dependent Effects of Transgenic 2D2 Mice Used to Induce Passive Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice

JMNBLF Kaplanb - Neuroimmunomodulation, 2023 - d-nb.info
Introduction: Multiple sclerosis (MS) is a neurodegenerative autoimmune disease that
worsens with age. Here, we examined the influence of age on passive experimental …

Age-Dependent Effects of Transgenic 2D2 Mice Used to Induce Passive Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice

JM Nichols, BLF Kaplan - Neuroimmunomodulation, 2023 - karger.com
Introduction: Multiple sclerosis (MS) is a neurodegenerative autoimmune disease that
worsens with age. Here, we examined the influence of age on passive experimental …

Inheritance of old mitochondria controls early CD8+ T cell fate commitment and is regulated by autophagy

M Borsa, AV Lechuga-Vieco, AH Kayvanjoo… - bioRxiv, 2024 - biorxiv.org
T cell immunity is impaired during ageing, particularly in memory responses needed for
efficient vaccination. Autophagy and asymmetric cell division (ACD) are cell biological …