Asymptomatic Plasmodium infection carriers represent a major threat to malaria control
worldwide as they are silent natural reservoirs and do not seek medical care. There are no …

Toll-like receptors (TLRs) play a key role in the induced immune response in malaria.
Although the potential roles of TLRs have been described, it is necessary to elucidate which …

Erythroid cells, specifically red blood cells (RBCs), are constantly exposed to highly reactive
radicals during cellular gaseous exchange. Such exposure often exceeds the cells' innate …

In recent malaria research, the complexity of the disease has been explored using machine
learning models via blood smear images, environmental, and even RNA-Seq data …

The replication of Plasmodium falciparum parasites within red blood cells (RBCs) causes
severe disease in humans, especially in Africa. Deleterious alleles like hemoglobin S are …

Abstract Background DDX39B (BAT1) encodes an RNA helicase known to regulate
expression of TNF and IL-6. Elevated levels of these two cytokines are associated with …

Common alleles tend to be more ancient than rare alleles. These common SNPs appeared
thousands of years ago and reflect intricate human evolution including various adaptations …

Background Genetic polymorphisms in the human immune system modulate susceptibility to
malaria. However, there is a paucity of data on the contribution of immunogenetic variants to …

Background Plasmodium falciparum infection during pregnancy is a major cause of poor
maternal health, adverse foetal outcome and infant mortality in sub-Saharan Africa. Genetic …

Background Plasmodium vivax can cause severe malaria. The total parasite biomass during
infections is correlated with the severity of disease but not necessarily quantified accurately …