As it is well known, messenger RNA has many regulatory regions along its sequence length.
One of them is the 5′ untranslated region (5'UTR), which itself contains many regulatory …

Cells sense biochemical, electrical, and mechanical cues in their environment that affect
their differentiation and behavior. Unlike biochemical and electrical signals, mechanical …

Kinetochores couple chromosomes to the mitotic spindle to segregate the genome during
cell division. An error correction mechanism drives the turnover of kinetochore-microtubule …

Accurate chromosome segregation relies on dynamic interactions between microtubules
(MTs) and the NDC80 complex, a major kinetochore MT-binding component …

Strong kinetochore-microtubule attachments are essential for faithful segregation of sister
chromatids during mitosis. The Dam1 and Ndc80 complexes are the main microtubule …

Sumoylation is a powerful regulatory system that controls many of the critical processes in
the cell, including DNA repair, transcriptional regulation, nuclear transport, and DNA …

Accurate mitosis requires kinetochores to make persistent, load-bearing attachments to
dynamic microtubule tips, thereby coupling chromosome movements to tip growth and …

Regulation of the outer kinetochore complex Ndc80 is essential to ensure correct
kinetochore-microtubule attachments during mitosis. Here, we present a novel mechanism …

Mis‐regulation (eg overproduction) of the human Ndc80/Hec1 outer kinetochore protein has
been associated with aneuploidy and tumourigenesis, but the genetic basis and underlying …

At metaphase in mitotic cells, pulling forces at the kinetochore‐microtubule interface create
tension by stretching the centromeric chromatin between oppositely oriented sister …