The interferon response protects cells from invading viral pathogens by transcriptionally
inducing the expression of interferon-stimulated genes (ISGs), some of which encode …

Recently, intestinal flora plays a vital role in the occurrence and development of tumors and
there is link between cancer immunotherapy and Akkermansia muciniphila (Akk). However …

Worldwide, cancer is still an area with high unmet medical need. Lead optimization efforts
towards structure-based drug design were employed to discover newly synthesized hetero …

Respiratory-related diseases are a leading cause of death in rheumatoid arthritis (RA) and
are disproportionately higher in men, which may be attributable to environmental risk factors …

Using a simple technique to prepare many uracil derivatives as Schiff base of uracil 4, bis 6-
amino [5-(1-(4-aryl) ethylidene) amino)] pyrimidine-2, 4-dione 5–12 by heating of 5, 6 …

Excessive inflammation is a major cause of morbidity and mortality in many viral infections
including influenza. Therefore, there is a need for therapeutic interventions that dampen and …

The mammalian host responds to viral infections by inducing expression of hundreds of
interferon-stimulated genes (ISGs). While the functional significance of many ISGs has yet to …

Type 2 innate lymphoid cells (ILC2s) perform vital functions in orchestrating humoral
immune responses, facilitating tissue remodelling, and ensuring tissue homeostasis …

Colorectal cancer (CRC) is a global pressing healthcare priority. Dysregulation of the
IL6/JAK2/STAT3 and p53/caspase downstreaming pathways are significantly involved in the …

To identify new steroidal agents with potential biological activities, we synthesized hybrid
steroids containing thiazole, pyrazole, isoxazole, thiophene or phthalazine moiety. Epi …