RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation
Abstract The Receptor for Advanced Glycation Endproducts [RAGE] is an evolutionarily
recent member of the immunoglobulin super-family, encoded in the Class III region of the …
recent member of the immunoglobulin super-family, encoded in the Class III region of the …
The role of insulin receptors and IGF-I receptors in cancer and other diseases
There is evidence, both in vitro and in vivo, that receptor tyrosine kinases play a key role in
the formation and progression of human cancer. In particular, the insulin-like growth factor …
the formation and progression of human cancer. In particular, the insulin-like growth factor …
Nuclear functions of the HMG proteins
R Reeves - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2010 - Elsevier
Although the three families of mammalian HMG proteins (HMGA, HMGB and HMGN)
participate in many of the same nuclear processes, each family plays its own unique role in …
participate in many of the same nuclear processes, each family plays its own unique role in …
Duplication of 7q34 in pediatric low‐grade astrocytomas detected by high‐density single‐nucleotide polymorphism‐based genotype arrays results in a novel BRAF …
In the present study, DNA from 28 pediatric low‐grade astrocytomas was analyzed using
Illumina HumanHap550K single‐nucleotide polymorphism oligonucleotide arrays. A novel …
Illumina HumanHap550K single‐nucleotide polymorphism oligonucleotide arrays. A novel …
A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma
G Salvatore, TC Nappi, P Salerno, Y Jiang, C Garbi… - Cancer research, 2007 - AACR
Here, we show that the anaplastic thyroid carcinoma (ATC) features the up-regulation of a
set of genes involved in the control of cell cycle progression and chromosome segregation …
set of genes involved in the control of cell cycle progression and chromosome segregation …
HMGA proteins as modulators of chromatin structure during transcriptional activation
High mobility group (HMG) proteins are the most abundant non-histone chromatin
associated proteins. HMG proteins bind to DNA and nucleosome and alter the structure of …
associated proteins. HMG proteins bind to DNA and nucleosome and alter the structure of …
Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR
M Winter, D Sombroek, I Dauth, J Moehlenbrink… - Nature cell …, 2008 - nature.com
The tumour suppressor HIPK2 is an important regulator of cell death induced by DNA
damage, but how its activity is regulated remains largely unclear. Here we demonstrate that …
damage, but how its activity is regulated remains largely unclear. Here we demonstrate that …
Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells
The p53 protein is the most studied tumor suppressor and the p53 pathway has been shown
to mediate cellular stress responses that are disrupted when cancer develops. After DNA …
to mediate cellular stress responses that are disrupted when cancer develops. After DNA …
HMGA and cancer
Long-standing studies have clearly established that the architectural chromatinic proteins
High Mobility Group A (HMGA) are among the most widely expressed cancer-associated …
High Mobility Group A (HMGA) are among the most widely expressed cancer-associated …