Significance: Recent clinical evidence identified anemia to be correlated with severe
complications of cardiovascular disease (CVD) such as bleeding, thromboembolic events …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from
aerobic metabolism, as a result of accidental electron leakage as well as regulated …

Background: Oxidative stress from elevated reactive oxygen species (ROS) has been
reported to induce cell apoptosis and may provide a means to target cancer cells. Celastrol …

Red Blood Cells (RBCs) need to deform and squeeze through narrow capillaries.
Decreased deformability of RBCs is, therefore, one of the factors that can contribute to the …

Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …

Red cell diseases encompass a group of inherited or acquired erythrocyte disorders that
affect the structure, function, or production of red blood cells (RBCs). These disorders can …

Redox-dependent processes influence most cellular functions, such as differentiation,
proliferation, and apoptosis. Mitochondria are at the center of these processes, as …

The field of antioxidants and free radicals is often perceived as focusing around the use of
antioxidant supplements to prevent human disease. In fact, antioxidants/free radicals …

Peroxiredoxins (Prxs) contain an active site cysteine that is sensitive to oxidation by H 2 O 2.
Mammalian cells express six Prx isoforms that are localized to various cellular …

It is well established that oxidative stress is an important cause of cell damage associated
with the initiation and progression of many diseases. Consequently, all air-living organisms …