Multiple sclerosis (MS) is a chronic and disabling disease that attacks the central nervous
system (CNS). The symptoms, progression, and severity of the disease are unpredictable …

The association of psoriasis (PsO) with other autoimmune and autoinflammatory diseases
has long been a topic of interest. Although previous studies have attempted to clarify the …

The likely pathogenic mechanisms of multiple sclerosis (MS) provide a sound rationale for
investigating the efficacy of drugs possessing immunosuppressive or immunomodulatory …

We have analyzed the activities of the antifolates pyrimethamine (PM), chlorcycloguanil
(CCG), WR99210, trimethoprim (TMP), methotrexate (MTX), and trimetrexate (TMX) against …

The folate derivatives folic acid (FA) and folinic acid (FNA) decrease the in vivo and in vitro
activities of antifolate drugs in Plasmodium falciparum. However, the effects of 5-methyl …

The emergence of artemisinin resistance could adversely impact the current strategy for
malaria treatment; thus, new drugs are urgently needed. A possible approach to developing …

Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system, with highly variable clinical course that most typically exhibits a relapsing …

Multiple sclerosis (MS) is a heterogeneous autoimmune disorder of the central nervous
system that is enigmatic, relapsing, and in some instances progressive. Prior to the …

BACKGROUND: Methotrexate, a toxic antimetabolite that limits cellular reproduction by
acting as an antagonist to folic acid, has been used to control autoimmune disease with …

It is widely accepted that the main common pathogenetic pathway in multiple sclerosis (MS)
involves an immune-mediated cascade initiated in the peripheral immune system and …