Dysregulated glutamatergic neurotransmission has been strongly implicated in the
pathophysiology of schizophrenia (SCZ). Recently, presynaptic modulation of glutamate …

Stress is known to alter cognitive functions, such as memory, and it has been linked to the
pathophysiology of mood and anxiety disorders. Chronic lithium treatment is used in some …

The hole‐board test has been used in rodents since the early 60s to measure exploratory
behavior, locomotor activity and cognitive function. The test is based on rodents' natural …

2, 5‐Hexanedione (2, 5‐HD) is the toxic metabolite of n‐hexane which is widely used as
solvent in numerous industries. The present study elucidated the precise mechanism of 2, 5 …

2, 5-Hexanedione (HD), a metabolite of n-hexane, causes central and peripheral
neuropathy leading to motor neuron deficits. Although chronic exposure to n-hexane is …

Exposure to n-hexane and its metabolite 2, 5-hexandione (HD) is a well-known cause of
neurotoxicity, particularly in the peripheral nervous system. To date, few studies have …

Occupational exposure and experimental intoxication with n-hexane or its metabolite 2, 5-
hexanedione (HD) produce a central-peripheral neuropathy. However, the mechanism …

n-Hexane is an organic solvent widely used in industry. 2, 5-Hexanedione (2, 5-HD), the
major neurotoxic metabolite of n-hexane, decreases the levels of neurofilaments (NFs) in …

Exposure chronically to n-hexane produces central-peripheral axonopathy mediated by 2, 5-
hexanedione (HD). Studies have shown neurofilament (NF) subunit proteins are decreased …

Biologic monitoring of occupational exposure to n-hexane has been routinely evaluated by
determining the urinary levels of total 2, 5-HD (Perbellini et al., 1990). More recently the …