Estrogens play an important role in the regulation of normal physiology, aging and many
disease states. Although the nuclear estrogen receptors have classically been described to …

The prevalence of left ventricular diastolic dysfunction (LVDD) sharply increases in women
after menopause and may lead to heart failure. While evidence suggests that estrogens …

Cardiovascular disease (CVD) is the leading cause of death globally for men and women.
Premenopausal women have a lower incidence of hypertension and other cardiovascular …

In this review, we aim to provide an overview of the recent advances in understanding
estrogen effects on the vascular endothelium. Epidemiological studies suggest the female …

Abstract Estrogens, predominantly 17β-estradiol, exert diverse effects throughout the body in
both normal and pathophysiology, during development and in reproductive, metabolic …

Pulmonary arterial hypertension (PAH) is a devastating and progressive disease with
marked morbidity and mortality. Even though being female represents one of the most …

The recent discovery of the G protein-coupled estrogen receptor (GPER) presents new
challenges and opportunities for understanding the physiology, pathophysiology, and …

Although the rapid effects of steroids, such as estrogen and aldosterone, were postulated
originally to be nongenomic, it is now appreciated that activation of such signaling pathways …

Our previous work showed that chronic activation of the membrane-bound estrogen receptor
GPR30/GPER significantly lowers blood pressure in ovariectomized hypertensive mRen2 …

Estrogen exerts protective effects on the cardiovascular system via three known estrogen
receptors: alpha (ERα), beta (ERß), and the G protein-coupled estrogen receptor (GPER) …