Spreading depression (SD) is a transient wave of near-complete neuronal and glial
depolarization associated with massive transmembrane ionic and water shifts. It is …

A modern understanding of how cerebral cortical lesions develop after acute brain injury is
based on Aristides Leão's historic discoveries of spreading depression and asphyxial/anoxic …

Cortical spreading depression (CSD) has been suggested to underlie migraine visual aura.
However, it has been challenging to test this hypothesis in human cerebral cortex. Using …

For decades, scientists who heard about synesthesia hearing colors, tasting words, seeing
colored pain just shrugged their shoulders or rolled their eyes. Now, as irrefutable evidence …

Spreading depression (SD) and the related hypoxic SD-like depolarization (HSD) are
characterized by rapid and nearly complete depolarization of a sizable population of brain …

Objective Topiramate, valproate, propranolol, amitriptyline, and methysergide have been
widely prescribed for migraine prophylaxis, but their mechanism or site of action is uncertain …

Although decreases in regional cerebral blood flow are known to occur in relation to
migraine headache, the pattern of the alterations in blood flow has not been precisely …

DON R. SWANSON*... tL· natural sciences... can be said to be a living organism developing
by the addition of little celh, a veritable body of knowledge proving itself to be such by the …

This book provides the first general and unified theory of visual discomfort. The theory is
based on the observation that people find certain visual stimuli uncomfortable, and that …

Background and Purpose—Cortical spreading depression (CSD) has been much studied
experimentally but never demonstrated unequivocally in human neocortex by direct …