Several cell types have been suggested as giving rise to chronic lymphocytic leukemia
(CLL), and these suggestions have reflected the sophistication of technology available at the …

Chromosomal abnormalities in chronic lymphocytic leukemia (CLL) are detected in up to
80% of patients. Among them, deletions of 11q, 13q, 17p, and trisomy 12 have a known …

Richter syndrome (RS) occurs in up to 15% of patients with chronic lymphocytic leukemia
(CLL). Although RS, usually represented by the histologic transformation to a diffuse large B …

Acute leukemia characterized by chromosomal rearrangements requires additional
molecular disruptions to develop into full-blown malignancy,, yet the cooperative …

Purpose: To further our understanding of the biology and prognostic significance of various
chromosomal 13q14 deletions in chronic lymphocytic leukemia (CLL). Experimental Design …

Deletion at 13q14 is detected by fluorescence in situ hybridization (FISH) in about 50% of
chronic lymphocytic leukemia (CLL). Although CLL with 13q deletion as the sole cytogenetic …

Background High-resolution genomic microarrays enable simultaneous detection of copy-
number aberrations such as the known recurrent aberrations in chronic lymphocytic …

The clinical heterogeneity that characterizes chronic lymphocytic leukemia (CLL), with
survival times ranging from months to decades, reflects its biological diversity. Our …

Chronic lymphocytic leukemia (CLL) is a clinically and biologically heterogeneous disease
where the majority of patients have an indolent disease course, while others may …

Purpose: The disease course of chronic lymphocytic leukemia (CLL) varies significantly
within cytogenetic groups. We hypothesized that high-resolution genomic analysis of CLL …