Effect of advanced parental age on pregnancy outcome and offspring health

C Zhang, L Yan, J Qiao - Journal of assisted reproduction and genetics, 2022 - Springer
Purpose Fertility at advanced age has become increasingly common, but the aging of
parents may adversely affect the maturation of gametes and the development of embryos …

Parental programming of offspring health: the intricate interplay between diet, environment, reproduction and development

V Batra, E Norman, HL Morgan, AJ Watkins - Biomolecules, 2022 - mdpi.com
As adults, our health can be influenced by a range of lifestyle and environmental factors,
increasing the risk for developing a series of non-communicable diseases such as type 2 …

The combination of DNA methylome and transcriptome revealed the intergenerational inheritance on the influence of advanced maternal age

L Hua, W Chen, Y Meng, M Qin, Z Yan… - Clinical and …, 2022 - Wiley Online Library
Background The number of women delivering at advanced maternal age (AMA;>= 35)
continuously increases in developed and high‐income countries. Large cohort studies have …

Maternal dysbiosis produces long-lasting behavioral changes in offspring

J Hudobenko, CM Di Gesù, PR Mooz, J Petrosino… - Molecular …, 2024 - nature.com
Advanced maternal age (AMA) is defined as a pregnancy in a woman older than 35 years of
age. AMA increases the risk for both maternal and neonatal complications, including …

Murine models of advanced maternal age: a systematic review and meta-analysis

J Dalton-O'Reilly, AEP Heazell, M Desforges… - …, 2023 - rep.bioscientifica.com
In brief Animal models have been developed to aid understanding of the increased
incidence of adverse pregnancy complications observed in women of advanced maternal …

[HTML][HTML] Vitamin D supplementation in mice with advanced maternal age and cognitive function of the offspring

D Li, K Wang, Z Yang, H Li, S Wang - American Journal of …, 2021 - ncbi.nlm.nih.gov
To investigate the effects of vitamin D supplementation before pregnancy on the offspring's
cognitive function in mice with advanced maternal age (AMA). Thirty-two-week-old female …

Considerations for designing and analysing inter-generational studies in rodents

L Dearden, SE Ozanne - Nature Metabolism, 2023 - nature.com
The environment experienced by an individual early in life has long-term health
consequences. Here we summarize key factors that should be considered when designing …

Maternal age at childbirth and the risk of attention-deficit/hyperactivity disorder and learning disability in offspring

L Gao, S Li, Y Yue, G Long - Frontiers in Public Health, 2023 - frontiersin.org
Background Studies have shown that young maternal age at childbirth can increase the risk
of attention-deficit/hyperactivity disorder (ADHD) in offspring, but a study of the US …

Prenatal gene-environment interactions mediate the impact of advanced maternal age on mouse offspring behavior

MM Ziętek, A Jaszczyk, AM Stankiewicz, S Sampino - Scientific Reports, 2024 - nature.com
Autism spectrum disorders encompass diverse neurodevelopmental conditions marked by
alterations in social communication and repetitive behaviors. Advanced maternal age is …

Influence of prenatal drug exposure, maternal inflammation, and parental aging on the development of autism spectrum disorder

A Sato, H Kotajima-Murakami, M Tanaka… - Frontiers in …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) affects reciprocal social interaction and produces abnormal
repetitive, restrictive behaviors and interests. The diverse causes of ASD are divided into …