Insulin, insulin-like growth factors (IGFs) and insulin-like peptides (ILPs) are important
regulators of metabolism, growth, reproduction and lifespan, and mechanisms of insulin/IGF …

Excess adipose fat accumulation, or obesity, is a growing problem worldwide in terms of
both the rate of incidence and the severity of obesity-associated metabolic disease. Adipose …

Inositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds
and fungi to mammals. Distinct classes of kinases generate different forms of energetic …

Objectives Genome-wide association studies (GWAS) have successfully revealed numerous
susceptibility loci for obesity. However, identifying the causal genes, pathways, and …

Removal of the 5′-end 7-methylguanosine cap structure is a critical step in the highly
regulated process of mRNA decay. The Nudix hydrolase, Dcp2, was identified as a first …

Loin muscle area (LMA) and loin muscle depth (LMD) are important traits influencing the
production performance of breeding pigs. However, the genetic architecture of these two …

Nudix hydrolases attract considerable attention for their wide range of specialized activities
in all domains of life. One particular group of Nudix phosphohydrolases (DIPPs), through …

Heart disease is the number one cause of human death worldwide. Numerous studies have
shown strong connections between obesity and cardiac malfunction in humans, but more …

Human GWAS of obesity have been successful in identifying loci associated with adiposity,
but for the most part, these are non-coding SNPs whose function, or even whose gene of …

Background: Heart failure (HF) is the most common cardiovascular diseases and the leading
cause of cardiovascular diseases related deaths. Increasing molecular targets have been …