Due to the pharmacological activities of quinazoline and quinazolinone scaffolds, it has
aroused great interest in medicinal chemists for the development of new drugs or drug …

The presence of N-heterocycles as an essential structural motif in a variety of biologically
active substances has stimulated the development of new strategies and technologies for …

Drug development has been a principal driving force in the rapid maturation of the field of
medicinal chemistry during the past several decades. During this period, the intriguing and …

Nitrogen-rich heterocycles, particularly quinazolines and quinazolinones, represent a
unique class of diversified frameworks displaying a broad spectrum of biological functions …

Abstract Properties of responsible for biological activity tetrazoles are considered. Examples
are given of active pharmaceutical ingredients of modern drugs containing the tetrazole ring …

Cancer is one of the major causes of worldwide human mortality. A wide range of cytotoxic
drugs are available on the market, and several compounds are in different phases of clinical …

Computer-aided drug design plays a vital role in drug discovery and development and has
become an indispensable tool in the pharmaceutical industry. Computational medicinal …

Heterocyclic rings have long piqued the interest of medicinal chemists. Quinazolinone is a
fused nitrogen‐based heterocyclic moiety. Some of quinazolinone derivatives have …

Present in more than one billion adults, hypertension is the most significant modifiable risk
factor for mortality resulting from cardiovascular disease. Although its pathogenesis is not yet …

The high potential of quinazolinone containing natural products and their derivatives in
medicinal chemistry led us to discover four novel series of 53 compounds of quinazolinone …