Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update

M Mehta, DS Dhanjal, KR Paudel, B Singh… - …, 2020 - Springer
Respiratory disorders, especially non-communicable, chronic inflammatory diseases, are
amongst the leading causes of mortality and morbidity worldwide. Respiratory diseases …

Angiocrine functions of organ-specific endothelial cells

S Rafii, JM Butler, BS Ding - Nature, 2016 - nature.com
Endothelial cells that line capillaries are not just passive conduits for delivering blood.
Tissue-specific endothelium establishes specialized vascular niches that deploy sets of …

[HTML][HTML] Characterization of the COPD alveolar niche using single-cell RNA sequencing

M Sauler, JE McDonough, TS Adams… - Nature …, 2022 - nature.com
Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide,
however our understanding of cell specific mechanisms underlying COPD pathobiology …

Cell death in the lung: the apoptosis–necroptosis axis

M Sauler, IS Bazan, PJ Lee - Annual review of physiology, 2019 - annualreviews.org
Regulated cell death is a major mechanism to eliminate damaged, infected, or superfluous
cells. Previously, apoptosis was thought to be the only regulated cell death mechanism; …

[HTML][HTML] Development of a multiomics model for identification of predictive biomarkers for COVID-19 severity: a retrospective cohort study

SK Byeon, AK Madugundu, K Garapati… - The Lancet Digital …, 2022 - thelancet.com
Background COVID-19 is a multi-system disorder with high variability in clinical outcomes
among patients who are admitted to hospital. Although some cytokines such as interleukin …

Cellular and molecular mechanisms of chronic obstructive pulmonary disease

PJ Barnes - Clinics in chest medicine, 2014 - chestmed.theclinics.com
Chronic obstructive pulmonary disease (COPD) involves chronic inflammation of the lung,
particularly in peripheral airways and parenchyma, which increases during acute …

[HTML][HTML] The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis

EP Schmidt, Y Yang, WJ Janssen, A Gandjeva… - Nature medicine, 2012 - nature.com
Sepsis, a systemic inflammatory response to infection, commonly progresses to acute lung
injury (ALI), an inflammatory lung disease with high morbidity. We postulated that sepsis …

Erythrocytes as a biological model for screening of xenobiotics toxicity

MR Farag, M Alagawany - Chemico-biological interactions, 2018 - Elsevier
Erythrocytes are the main cells in circulation. They are devoid of internal membrane
structures and easy to be isolated and handled providing a good model for different assays …

[HTML][HTML] The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD

G Günes Günsel, TM Conlon, A Jeridi, R Kim… - Nature …, 2022 - nature.com
Extravasation of monocytes into tissue and to the site of injury is a fundamental
immunological process, which requires rapid responses via post translational modifications …

[HTML][HTML] Pathogenesis of chronic obstructive pulmonary disease

RM Tuder, I Petrache - The Journal of clinical investigation, 2012 - Am Soc Clin Investig
The current epidemic of chronic obstructive pulmonary disease (COPD) has produced a
worldwide health care burden, approaching that imposed by transmittable infectious …