The isoxazolidine ring represents one of the privileged structures in medicinal chemistry,
and there have been an increasing number of studies on isoxazolidine and isoxazolidine …

The interaction of small molecules with DNA plays an essential role in many biological
processes. As DNA is often the target for majority of anticancer and antibiotic drugs, study …

Organic transformations that result in the formation of multiple covalent bonds within the
same reaction are some of the most powerful tools in synthetic organic chemistry …

Imines (azomethines), iminium salts, and related compounds have been used as
electrophiles for ionic bond constructions (eg in the Mannich reaction) for many years, but …

The Diels-Alder cycloaddition has become one of the most used and dependable reactions
in all of organic synthesis, t One reason for its popularity is that asynunetric versions of the …

Biocatalytic approaches have yielded efficient total syntheses of the major Amaryllidaceae
alkaloids, all based on the key enzymatic dioxygenation of suitable aromatic precursors …

The nitroso Diels–Alder (NDA) reaction is an attractive strategy for the synthesis of 3, 6-
dihydro-1, 2-oxazines and 1-amino-4-hydroxy-2-ene derivatives. Herein we report the Cu (I) …

Bicyclo [1.1. 0] butanes (BCBs), a class of highly strained saturated bicyclic carbocycles,
have garnered increasing attention in recent years. Functionalization of BCBs provides an …

The expedient and fully stereocontrolled synthesis of epothilones A and B are described.
The routes described make extensive study of nitrile oxide cycloadditions as surrogates for …

This communication presents studies that nitroso Diels− Alder adduct has been furnished in
uniformly high yield and high enantioselectivity using nitrosopyridine as a substrate and …