Pathophysiological and cognitive mechanisms of fatigue in multiple sclerosis

ZM Manjaly, NA Harrison, HD Critchley… - Journal of Neurology …, 2019 - jnnp.bmj.com
Fatigue is one of the most common symptoms in multiple sclerosis (MS), with a major impact
on patients' quality of life. Currently, treatment proceeds by trial and error with limited …

Fatigue as a symptom or comorbidity of neurological diseases

IK Penner, F Paul - Nature Reviews Neurology, 2017 - nature.com
Fatigue, best described as an overwhelming feeling of tiredness and exhaustion, occurs in
the context of various neurological diseases. The high prevalence of fatigue as either a …

Distinguishing between fatigue and fatigability in multiple sclerosis

RM Enoka, AM Almuklass, M Alenazy… - … and Neural Repair, 2021 - journals.sagepub.com
Fatigue is one of the most common debilitating symptoms reported by persons with multiple
sclerosis (MS). It reflects feelings of tiredness, lack of energy, low motivation, and difficulty in …

[HTML][HTML] Neuropsychiatric symptoms of multiple sclerosis: state of the art

C Silveira, R Guedes, D Maia, R Curral… - Psychiatry …, 2019 - ncbi.nlm.nih.gov
Multiple Sclerosis (MS) is a chronic disabling neuroinflammatory disease. Psychiatric
manifestations have a high prevalence in MS patients and may worsen the illness …

The dopamine imbalance hypothesis of fatigue in multiple sclerosis and other neurological disorders

E Dobryakova, HM Genova, J DeLuca… - Frontiers in …, 2015 - frontiersin.org
Fatigue is one of the most pervasive symptoms of multiple sclerosis (MS), and has
engendered hundreds of investigations on the topic. While there is a growing literature using …

Fatigue in multiple sclerosis–insights into evaluation and management

SS Ayache, MA Chalah - Neurophysiologie Clinique/Clinical …, 2017 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the
central nervous system, characterized by the accumulation of numerous neurological …

Role of inflammation in human fatigue: relevance of multidimensional assessments and potential neuronal mechanisms

B Karshikoff, T Sundelin, J Lasselin - Frontiers in immunology, 2017 - frontiersin.org
Fatigue is a highly disabling symptom in various medical conditions. While inflammation has
been suggested as a potential contributor to the development of fatigue, underlying …

Vitamin D in the prevention, prediction and treatment of neurodegenerative and neuroinflammatory diseases

P Koduah, F Paul, JM Dörr - Epma Journal, 2017 - Springer
Vitamin D research has gained increased attention in recent times due to its roles beyond
bone health and calcium homeostasis, such as immunomodulation. In some parts of the …

Multiple sclerosis and fatigue: a review on the contribution of inflammation and immune-mediated neurodegeneration

R Patejdl, IK Penner, TK Noack, UK Zettl - Autoimmunity reviews, 2016 - Elsevier
Multiple sclerosis (MS) is an immune mediated disease of the central nervous system (CNS)
and the leading cause of non-traumatic disability among young and middle-aged adults in …

Fatigue, depression, and pain in multiple sclerosis: how neuroinflammation translates into dysfunctional reward processing and anhedonic symptoms

H Heitmann, TFM Andlauer, T Korn… - Multiple Sclerosis …, 2022 - journals.sagepub.com
Fatigue, depression, and pain affect the majority of multiple sclerosis (MS) patients, which
causes a substantial burden to patients and society. The pathophysiology of these …