Integrated lncRNA function upon genomic and epigenomic regulation

AB Herman, D Tsitsipatis, M Gorospe - Molecular Cell, 2022 - cell.com
Although some long noncoding (lnc) RNAs are known since the 1950s, the past 25 years
have uncovered myriad lncRNAs with diverse sequences, structures, and functions. The …

LNCcation: lncRNA localization and function

MC Bridges, AC Daulagala, A Kourtidis - Journal of Cell Biology, 2021 - rupress.org
Subcellular localization of RNAs has gained attention in recent years as a prevalent
phenomenon that influences numerous cellular processes. This is also evident for the large …

[HTML][HTML] Human brown adipocyte thermogenesis is driven by β2-AR stimulation

DP Blondin, S Nielsen, EN Kuipers, MC Severinsen… - Cell metabolism, 2020 - cell.com
Stimulation of brown adipose tissue (BAT) thermogenesis in humans has emerged as an
attractive target to improve metabolic health. Pharmacological stimulations targeting the β 3 …

The evolving view of thermogenic adipocytes—ontogeny, niche and function

F Shamsi, CH Wang, YH Tseng - Nature Reviews Endocrinology, 2021 - nature.com
The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …

An update on brown adipose tissue biology: a discussion of recent findings

RC Gaspar, JR Pauli, GI Shulman… - American Journal of …, 2021 - journals.physiology.org
Brown adipose tissue (BAT) has been encouraged as a potential treatment for obesity and
comorbidities due to its thermogenic activity capacity and contribution to energy expenditure …

[图书][B] RNA, the epicenter of genetic information

J Mattick, P Amaral - 2023 - library.oapen.org
The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

LncRNA-mediated adipogenesis in different adipocytes

P Zhang, S Wu, Y He, X Li, Y Zhu, X Lin… - International Journal of …, 2022 - mdpi.com
Long-chain noncoding RNAs (lncRNAs) are RNAs that do not code for proteins, widely
present in eukaryotes. They regulate gene expression at multiple levels through different …

The lncRNA HOXA11os regulates mitochondrial function in myeloid cells to maintain intestinal homeostasis

L Shmuel-Galia, F Humphries, T Vierbuchen, Z Jiang… - Cell Metabolism, 2023 - cell.com
This study reveals a previously uncharacterized mechanism to restrict intestinal
inflammation via a regulatory RNA transcribed from a noncoding genomic locus. We …

CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease

E Tsagkaraki, SM Nicoloro, T DeSouza… - Nature …, 2021 - nature.com
Obesity and type 2 diabetes are associated with disturbances in insulin-regulated glucose
and lipid fluxes and severe comorbidities including cardiovascular disease and …

LncRNAs in cancer: from garbage to junk

M Aprile, V Katopodi, E Leucci, V Costa - Cancers, 2020 - mdpi.com
Simple Summary Long non-coding RNAs (lncRNAs) are generally defined as transcripts
longer than 200 nucleotides and not coding for proteins. This review provides an overview of …