With the development of modern high-throughput omic measurement platforms, it has
become essential for biomedical studies to undertake an integrative (combined) approach to …

One of the most useful metaphors for driving scientific and engineering progress has been
that of the “machine”. Much controversy exists about the applicability of this concept in the …

Discrepancy between the abundance of cognate protein and RNA molecules is frequently
observed. A theoretical understanding of this discrepancy remains elusive, and it is …

Simple Summary MicroRNAs (miRNA) inhibit the translation and enhance the degradation
of their target mRNAs, but only moderately. Paradoxically, miRNAs and their target mRNAs …

Background The robust storage, updating and utilization of information are necessary for the
maintenance and perpetuation of dynamic systems. These systems can exist as constructs …

The miRNA pathway has three segments—biogenesis, targeting and downstream regulatory
effectors. We aimed to better understand their cellular control by exploring the miRNA …

The paper examines the impact of the physics of extremely scaled information processing
devices and systems, with a focus on energy minimization. Architectural implications are …

Early attention has focused on DNA because its properties are extremely attractive as a
basis for a computational system. In this paper, we have proposed a new framework for …

Gene expression is time-consuming, and the delay from transcription activation to produced
proteins is sequentially longer from bacteria to yeast and to humans. How human cells …

Our understanding of biological systems has improved dramatically due to decades of
exploration. This process has been accelerated even further during the past ten years …