Review of serial femtosecond crystallography including the COVID-19 pandemic impact and future outlook

S Botha, P Fromme - Structure, 2023 - cell.com
Serial femtosecond crystallography (SFX) revolutionized macromolecular crystallography
over the past decade by enabling the collection of X-ray diffraction data from nano-or …

Bridging the microscopic divide: a comprehensive overview of micro-crystallization and in vivo crystallography

LMG Chavas, F Coulibaly, D Garriga - IUCrJ, 2024 - journals.iucr.org
A series of events underscoring the significant advancements in micro-crystallization and in
vivo crystallography were held during the 26th IUCr Congress in Melbourne, positioning …

Modular droplet injector for sample conservation providing new structural insight for the conformational heterogeneity in the disease-associated NQO1 enzyme

D Doppler, M Sonker, A Egatz-Gomez, A Grieco… - Lab on a Chip, 2023 - pubs.rsc.org
Droplet injection strategies are a promising tool to reduce the large amount of sample
consumed in serial femtosecond crystallography (SFX) measurements at X-ray free electron …

[PDF][PDF] Droplet microfluidics for time-resolved serial crystallography

J Stubbs, T Hornsey, N Hanrahan, LB Esteban… - IUCrJ, 2024 - journals.iucr.org
Serial crystallography requires large numbers of microcrystals and robust strategies to
rapidly apply substrates to initiate reactions in time-resolved studies. Here, we report the use …

Cyclic Olefin Copolymer-Based Fixed-Target Sample Delivery Device for Protein X-ray Crystallography

A Manna, M Sonker, D Koh, M Steiger… - Analytical …, 2024 - ACS Publications
Serial macromolecular X-ray crystallography plays an important role in elucidating protein
structures and consequently progressing the field of targeted therapeutics. The use of …

[HTML][HTML] Advanced manufacturing provides tailor-made solutions for crystallography with x-ray free-electron lasers

L Paulson, SR Narayanasamy, ML Shelby… - Structural …, 2024 - pubs.aip.org
Serial crystallography at large facilities, such as x-ray free-electron lasers and synchrotrons,
evolved as a powerful method for the high-resolution structural investigation of proteins that …

Advanced manufacturing provides tailor-made solutions for crystallography with x-ray free-electron lasers

L Paulson, SR Narayanasamy, ML Shelby, M Frank… - Structural Dynamics, 2024 - osti.gov
Serial crystallography at large facilities, such as x-ray free-electron lasers and synchrotrons,
evolved as a powerful method for the high-resolution structural investigation of proteins that …

Minimized Sample Consumption for Time-Resolved Serial Crystallography Applied to the Redox Cycle of Human NQO1

D Doppler, A Grieco, D Koh, A Manna, A Ansari… - bioRxiv, 2024 - biorxiv.org
Sample consumption for serial femtosecond crystallography (SFX) with X-ray free electron
lasers (XFELs) remains a major limitation preventing broader use of this powerful …

Optimized Sample Delivery for Time Resolved Serial Crystallography at X-ray Free Electron Lasers

D Doppler - 2024 - search.proquest.com
Abstract Serial Femtosecond Crystallography (SFX) is a powerful X-ray diffraction technique
that reveals ultrafast biomolecular dynamics at physiological temperatures. Delivering …