Large animal models for the study of tendinopathy
G Zhang, X Zhou, S Hu, Y Jin, Z Qiu - Frontiers in Cell and …, 2022 - frontiersin.org
Tendinopathy has a high incidence in athletes and the aging population. It can cause pain
and movement disorders, and is one of the most difficult problems in orthopedics. Animal …
and movement disorders, and is one of the most difficult problems in orthopedics. Animal …
[HTML][HTML] Translational therapy from preclinical animal models for muscle degeneration after rotator cuff injury
Chronic rotator cuff tears are debilitating diseases which significantly affect patients' quality
of life and pose substantial financial burden to the society. The intraoperative reparability of …
of life and pose substantial financial burden to the society. The intraoperative reparability of …
[HTML][HTML] 过度机械拉伸应力通过Piezo1 介导肌腱细胞凋亡的作用及机制研究
陈墨龙， 陈万， 唐康来 - 2023 - aammt.tmmu.edu.cn
目的探索机械敏感离子通道蛋白Piezo1 在过度机械拉伸应力诱导肌腱细胞凋亡中的作用机制.
方法分离并培养8 周龄雄性C57 小鼠(n= 20, 体质量22~ 26 g) 的肌腱细胞, 采用Flexcell …
方法分离并培养8 周龄雄性C57 小鼠(n= 20, 体质量22~ 26 g) 的肌腱细胞, 采用Flexcell …
Structural Musculotendinous Parameters That Predict Failed Tendon Healing After Rotator Cuff Repair
MGL Olthof, M Flück, P Borbas… - … Journal of Sports …, 2023 - journals.sagepub.com
Background: Healing of the rotator cuff after repair constitutes a major clinical challenge with
reported high failure rates. Identifying structural musculotendinous predictors for failed …
reported high failure rates. Identifying structural musculotendinous predictors for failed …
Cooperation between myofibril growth and costamere maturation in human cardiomyocytes
H Shi, C Wang, BZ Gao, JH Henderson… - … in Bioengineering and …, 2022 - frontiersin.org
Costameres, as striated muscle-specific cell adhesions, anchor both M-lines and Z-lines of
the sarcomeres to the extracellular matrix. Previous studies have demonstrated that …
the sarcomeres to the extracellular matrix. Previous studies have demonstrated that …
[HTML][HTML] Down-regulation of mitochondrial metabolism after tendon release primes lipid accumulation in rotator cuff muscle
Atrophy and fat accumulation are debilitating aspects of muscle diseases and are rarely
prevented. Using a vertical approach combining anatomic techniques with omics …
prevented. Using a vertical approach combining anatomic techniques with omics …
Transcriptional time course after rotator cuff repair in 6 month old female rabbits
LS Vasquez-Bolanos, MC Gibbons, S Ruoss… - Frontiers in …, 2023 - frontiersin.org
Introduction: Rotator cuff tears are prevalent in the population above the age of 60. The
disease progression leads to muscle atrophy, fibrosis, and fatty infiltration, which is not …
disease progression leads to muscle atrophy, fibrosis, and fatty infiltration, which is not …
[HTML][HTML] 动物模型在肩袖损伤研究中的应用
刘萍， 朱威宏， 刘骞 - Journal of Central South University Medical …, 2021 - ncbi.nlm.nih.gov
肩袖损伤是肩关节疼痛和功能障碍的最常见原因。 理想的肩关节动物模型应具有与人相近的
解剖结构和功能， 并能模拟肌腱损伤后的微环境变化。 目前已有大鼠、 小鼠、 兔、 羊、 犬 …
解剖结构和功能， 并能模拟肌腱损伤后的微环境变化。 目前已有大鼠、 小鼠、 兔、 羊、 犬 …
[HTML][HTML] Focal adhesion kinase coordinates costamere-related JNK signaling with muscle fiber transformation after Achilles tenotomy and tendon reconstruction
C Ferrié, S Kasper, F Wanivenhaus, M Flück - Experimental and molecular …, 2019 - Elsevier
Achilles tendon rupture necessitates rapid tendon reattachment to reinstate plantar flexion
before affected muscles deteriorate through muscle fiber atrophy and transformation. The …
before affected muscles deteriorate through muscle fiber atrophy and transformation. The …