The autophagic pathway involves the encapsulation of substrates in double-membraned
vesicles, which are subsequently delivered to the lysosome for enzymatic degradation and …

Pulmonary fibrosis is a chronic and fatal lung disease that significantly impacts the aging
population globally. To date, anti-fibrotic, immunosuppressive, and other adjunct therapy …

Idiopathic pulmonary fibrosis (IPF) is a devastating lung disorder with increasing incidence.
Mitochondrial oxidative stress in alveolar macrophages is directly linked to pulmonary …

Idiopathic pulmonary fibrosis (IPF) is a disease with relentless course and limited
therapeutic options. Nintedanib (BIBF-1120) is a multiple tyrosine kinase inhibitor recently …

Aging is an inevitable and complex natural phenomenon due to the increase in age. Cellular
senescence means a non-proliferative but viable cellular physiological state. It is the basis of …

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and usually lethal disease
associated with aging. However, the molecular mechanisms of the aging process that …

Abstract The herbicide paraquat (PQ; 1, 1'-dimethyl-4, 4'-bipyridylium dichloride) is a highly
toxic organic heterocyclic herbicide that has been widely used in agricultural settings. Since …

Idiopathic pulmonary fibrosis (IPF) is a chronic age-related lung disease with high mortality
that is characterized by abnormal scarring of the lung parenchyma. There has been a recent …

As an evolutionarily conserved intracellular degradation pathway, autophagy is essential to
cellular homeostasis. Several studies have demonstrated that autophagy showed an …

Lysosomal-mediated degradation of intracellular lipids, proteins and organelles, known as
autophagy, represents a inducible adaptive response to lung injury resulting from exposure …