Age-associated B cells (ABCs) are a transcriptionally and functionally unique B cell
population. In addition to arising with age and following infection, ABCs are expanded …

The past few years have provided important insights into the genetic architecture of systemic
autoimmunity through aggregation of findings from genome-wide association studies …

Age-associated B cells (ABCs) are a recently identified, unique B cell population that
displays both protective and pathogenic characteristics, depending on the context. A major …

B cells expressing the transcription factor T-bet are found to have a protective role in viral
infections, but are also considered major players in the onset of different types of …

Epstein–Barr virus (EBV) is an aetiologic risk factor for the development of multiple sclerosis
(MS). However, the role of EBV-infected B cells in the immunopathology of MS is not well …

Gammaherpesviruses are species-specific, ubiquitous pathogens that establish lifelong
infection in their hosts and are associated with cancers, including B cell lymphomas. Type I …

Objectives B cells are important in the pathogenesis of multiple sclerosis. It is yet unknown
which subsets may be involved, but atypical B cells have been proposed as mediators of …

EBV infection has long been suspected to play a role in the development of autoimmune
diseases. Interestingly, a recently published study has provided the strongest evidence to …

Infection has long been hypothesized as the cause of multiple sclerosis (MS), and recent
evidence for Epstein-Barr virus (EBV) as the trigger of MS is clear and compelling. This …

Adaptive immunity plays a profound role in atherosclerosis pathogenesis by regulating
antigen-specific responses, inflammatory signaling and antibody production. However, as …