[HTML][HTML] Antioxidant response elements: Discovery, classes, regulation and potential applications

A Raghunath, K Sundarraj, R Nagarajan, F Arfuso… - Redox biology, 2018 - Elsevier
Exposure to antioxidants and xenobiotics triggers the expression of a myriad of genes
encoding antioxidant proteins, detoxifying enzymes, and xenobiotic transporters to offer …

Natural allies for heart health: Nrf2 Activation and cardiovascular disease management

SU Khan, SU Khan, M Suleman, MU Khan… - Current Problems in …, 2024 - Elsevier
The term “cardiovascular diseases”(CVD) refers to various ailments that affect the heart and
blood vessels, including myocardial ischemia, congenital heart defects, heart failure …

Inhibition of NGLY1 inactivates the transcription factor Nrf1 and potentiates proteasome inhibitor cytotoxicity

FM Tomlin, UIM Gerling-Driessen, YC Liu… - ACS central …, 2017 - ACS Publications
Proteasome inhibitors are used to treat blood cancers such as multiple myeloma (MM) and
mantle cell lymphoma. The efficacy of these drugs is frequently undermined by acquired …

NFE2L3 controls colon cancer cell growth through regulation of DUX4, a CDK1 inhibitor

M Bury, B Le Calve, F Lessard, T Dal Maso, J Saliba… - Cell Reports, 2019 - cell.com
Constitutive nuclear factor κB (NF-κB) activation is a hallmark of colon tumor growth. Cyclin-
dependent kinases (CDKs) are critical cell-cycle regulators, and inhibition of CDK activity …

The characteristics and roles of β‐TrCP1/2 in carcinogenesis

Y Bi, D Cui, X Xiong, Y Zhao - The FEBS journal, 2021 - Wiley Online Library
β‐transducin repeat‐containing protein (β‐TrCP), one of the well‐characterized F‐box
proteins, acts as a substrate receptor and constitutes an active SCFβ‐TrCP E3 ligase with a …

Roles of CNC transcription factors NRF1 and NRF2 in cancer

H Sekine, H Motohashi - Cancers, 2021 - mdpi.com
Simple Summary Although NRF1 (nuclear factor erythroid 2-like 1; NFE2L1) and NRF2
(nuclear factor erythroid 2-like 2; NFE2L2) belong to the CNC (cap 'n'collar) transcription …

Proximity proteomic analysis of the NRF family reveals the Parkinson's disease protein ZNF746/PARIS as a co-complexed repressor of NRF2

KM LaPak, S Saeidi, I Bok, NT Wamsley, IB Plutzer… - Science …, 2023 - science.org
The nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor activates
cytoprotective and metabolic gene expression in response to various electrophilic stressors …

Defining the functional targets of Cap 'n'collar transcription factors NRF1, NRF2, and NRF3

L Ibrahim, J Mesgarzadeh, I Xu, ET Powers… - Antioxidants, 2020 - mdpi.com
The NRF transcription factors NRF1, NRF2, and NRF3, are a subset of Cap 'n'collar
transcriptional regulators which modulate the expression of genes harboring antioxidant …

Roles of NRF3 in the hallmarks of cancer: proteasomal inactivation of tumor suppressors

A Kobayashi - Cancers, 2020 - mdpi.com
Simple Summary This review summarizes recent advances in our understanding of the
physiological roles of the NFE2-related factor 2 (NRF2)-related transcription factor NRF3 in …

Long non-coding RNA EBLN3P regulates UHMK1 expression by sponging miR-323a-3p and promotes colorectal cancer progression

X Xu, W Song, J Li, Z Huang, Y Liu, Q Bao… - Frontiers in …, 2021 - frontiersin.org
Background: Growing studies have demonstrated that long non-coding RNA (lncRNA) can
act as crucial roles during the progression of various tumors, including colorectal carcinoma …