Summary c-MYC controls global gene expression and regulates cell proliferation, cell
differentiation, cell cycle, metabolism and apoptosis. According to some estimates, MYC is …

The transcription factor and oncoprotein MYC is a potent driver of many human cancers and
can regulate numerous biological activities that contribute to tumorigenesis. How a single …

MYC-driven medulloblastomas (MB) are highly aggressive pediatric brain tumors with poor
outcomes, and effective therapies remain limited despite intensive multimodal treatments …

Among the 'most wanted'targets in cancer therapy is the oncogene MYC, which coordinates
key transcriptional programs in tumor development and maintenance. It has, however, long …

The MYC protooncogene functions as a universal amplifier of transcription through
interaction with numerous factors and complexes that regulate almost every cellular process …

High-intensity transcription and replication supercoil DNA to levels that can impede or halt
these processes. As a potent transcription amplifier and replication accelerator, the proto …

Mounting evidence is identifying human cytomegalovirus (HCMV) as a potential oncogenic
virus. HCMV has been detected in malignant gliomas. EZH2 and Myc play a potential …

Myc is a powerful transcription factor implicated in epigenetic reprogramming, cellular
plasticity, and rapid growth as well as tumorigenesis. Cancer in skeletal muscle is extremely …

Background Human cytomegalovirus (HCMV) infection has been actively implicated in
complex neoplastic processes. Beyond oncomodulation, the molecular mechanisms that …

Cancer is a leading cause of death worldwide, resulting in∼ 10 million deaths in 2020.
Major oncogenic effectors are the Myc proto-oncogene family, which consists of three …