Normal maintenance of human motivation depends on the integrity of subcortical structures
that link the prefrontal cortex with the limbic system. Structural and functional disruption of …

In the long-term, with progression of the illness, Parkinson's disease dementia affects up to
90% of patients with Parkinson's disease. With increasing life expectancy in western …

A dopaminergic deficiency in patients with Parkinson's disease (PD) causes abnormalities of
movement, behaviour, learning, and emotions. The main motor features (ie, tremor, rigidity …

This review discusses the cerebral plasticity, and the role of the cortico-striatal system in
particular, observed as one is learning or planning to execute a newly learned motor …

Classical accounts of the pathophysiology of Parkinson's disease have emphasized
degeneration of dopaminergic nigrostriatal neurons with consequent dysfunction of cortico …

Relatively subtle cognitive disturbances may be present from the initial stages of Parkinson's
disease (PD) that progress in many patients to a more severe cognitive impairment and …

Objective To examine the integrity of the default mode network in patients with Parkinson
disease (PD). Previous functional neuroimaging experiments have studied executive deficits …

In recent years, a common approach to understanding how the basal ganglia contribute to
learning and memory in humans has been to study the deficits that occur in patients with …

The basal ganglia have traditionally been viewed as motor processing nuclei; however,
functional neuroimaging evidence has implicated these structures in more complex …

Objective: To examine functional connectivity within the basal ganglia network (BGN) in a
group of cognitively normal patients with early Parkinson disease (PD) on and off medication …