Blood and lymphatic vessels pervade almost all body tissues and have numerous essential
roles in physiology and disease. The inner lining of these networks is formed by a single …

The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Zebrafish is a powerful model for forward genetics. Reverse genetic approaches are limited
by the time required to generate stable mutant lines. We describe a system for gene …

Hematopoiesis is a complex process with a variety of different signaling pathways
influencing every step of blood cell formation from the earliest precursors to final …

Heart disease is the leading cause of death worldwide. Despite decades of research, most
heart pathologies have limited treatments, and often the only curative approach is heart …

The lateral plate mesoderm (LPM) forms the progenitor cells that constitute the heart and
cardiovascular system, blood, kidneys, smooth muscle lineage and limb skeleton in the …

Our vasculature plays diverse and critical roles in homeostasis and disease. In recent
decades, the use of zebrafish has driven our understanding of vascular development into …

Endothelial cells (ECs), which line blood and lymphatic vessels, are generally described to
come from the lateral plate mesoderm despite experimental evidence for a broader source …

Cellular responses to injury are crucial for complete tissue regeneration, but their underlying
processes remain incompletely elucidated. We have previously reported that myeloid …

Hepatic hydrothorax (HH) is the presence of pleural effusion in a patient with cirrhosis
without evidence of other cardiopulmonary disease. It occurs in 5%-15% of patients with …