Microorganisms that invade a vertebrate host are initially recognized by the innate immune system through germline-encoded pattern-recognition receptors (PRRs). Several classes of …
Immunity in higher organisms can be broadly categorized into adaptive immunity and innate immunity. Adaptive immunity is mediated by clonally distributed T and B lymphocytes which …
H Hemmi, T Kaisho, O Takeuchi, S Sato, H Sanjo… - Nature …, 2002 - nature.com
The imidazoquinoline compounds imiquimod and R-848 are low-molecular-weight immune response modifiers that can induce the synthesis of interferon-α and other cytokines in a …
L Karapetyan, JJ Luke, D Davar - OncoTargets and therapy, 2020 - Taylor & Francis
Abstract Toll-like receptor 9 (TLR9) is a pattern recognition receptor that is predominantly located intracellularly in immune cells, including dendritic cells, macrophages, natural killer …
K Honda, H Yanai, H Negishi, M Asagiri, M Sato… - Nature, 2005 - nature.com
The type-I interferon (IFN-α/β) response is critical to immunity against viruses and can be triggered in many cell types by cytosolic detection of viral infection, or in differentiated …
V Hornung, S Rothenfusser, S Britsch… - The Journal of …, 2002 - journals.aai.org
The Toll-like receptor (TLR) 9 is critical for the recognition of immunostimulatory CpG motifs but may cooperate with other TLRs. We analyzed TLR1–10 mRNA expression by using …
K Honda, T Taniguchi - Nature Reviews Immunology, 2006 - nature.com
The interferon-regulatory factor (IRF) family of transcription factors was initially found to be involved in the induction of genes that encode type I interferons. IRFs have now been shown …
Plasmacytoid dendritic cells (pDCs) are important mediators of antiviral immunity through their ability to produce large amounts of type I interferons (IFNs) on viral infection. This …