The impact of stress and major depressive disorder on hippocampal and medial prefrontal cortex morphology
EL Belleau, MT Treadway, DA Pizzagalli - Biological psychiatry, 2019 - Elsevier
Volumetric reductions in the hippocampus and medial prefrontal cortex (mPFC) are among
the most well-documented neural abnormalities in major depressive disorder (MDD) …
the most well-documented neural abnormalities in major depressive disorder (MDD) …
Consensus paper: cerebellum and emotion
Over the past three decades, insights into the role of the cerebellum in emotional processing
have substantially increased. Indeed, methodological refinements in cerebellar lesion …
have substantially increased. Indeed, methodological refinements in cerebellar lesion …
White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group
Alterations in white matter (WM) microstructure have been implicated in the pathophysiology
of major depressive disorder (MDD). However, previous findings have been inconsistent …
of major depressive disorder (MDD). However, previous findings have been inconsistent …
Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group
The pattern of structural brain alterations associated with major depressive disorder (MDD)
remains unresolved. This is in part due to small sample sizes of neuroimaging studies …
remains unresolved. This is in part due to small sample sizes of neuroimaging studies …
Prevalencia, causas y tratamiento de la depresión Mayor
EA Pérez-Padilla, VM Cervantes-Ramírez… - Revista …, 2017 - scielo.org.mx
La depresión mayor representa un problema de salud pública debido a su alta prevalencia.
La etiología de la depresión es compleja ya que en ella intervienen factores psicosociales …
La etiología de la depresión es compleja ya que en ella intervienen factores psicosociales …
Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder …
The neuro-anatomical substrates of major depressive disorder (MDD) are still not well
understood, despite many neuroimaging studies over the past few decades. Here we …
understood, despite many neuroimaging studies over the past few decades. Here we …
How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans
T Frodl, V O'Keane - Neurobiology of disease, 2013 - Elsevier
There is evidence that excessive stress exposure of the brain, mediated through the
neurotoxic effects of cortisol and possibly neuroinflammation, causes damage to brain …
neurotoxic effects of cortisol and possibly neuroinflammation, causes damage to brain …
The GABAergic deficit hypothesis of major depressive disorder
B Luscher, Q Shen, N Sahir - Molecular psychiatry, 2011 - nature.com
Increasing evidence points to an association between major depressive disorders (MDDs)
and diverse types of GABAergic deficits. In this review, we summarize clinical and preclinical …
and diverse types of GABAergic deficits. In this review, we summarize clinical and preclinical …
Gray matter abnormalities in major depressive disorder: a meta-analysis of voxel based morphometry studies
BACKGROUND: Voxel-based morphometry (VBM) has been widely used to quantify
structural brain changes associated with Major Depressive Disorder (MDD). While some …
structural brain changes associated with Major Depressive Disorder (MDD). While some …
[HTML][HTML] Pathophysiology of depression: do we have any solid evidence of interest to clinicians?
G Hasler - World psychiatry, 2010 - ncbi.nlm.nih.gov
Due to the clinical and etiological heterogeneity of major depressive disorder, it has been
difficult to elucidate its pathophysiology. Current neurobiological theories with the most valid …
difficult to elucidate its pathophysiology. Current neurobiological theories with the most valid …