[HTML][HTML] The emerging role of immunotherapy in head and neck squamous cell carcinoma (HNSCC): anti-tumor immunity and clinical applications

P Economopoulou, C Perisanidis… - Annals of …, 2016 - ncbi.nlm.nih.gov
Head and neck squamous cell carcinoma (HNSCC) carries a poor prognosis, with low
survival rates for advanced stage tumors and minimal improvement in survival trends …

CK2 in cancer: cellular and biochemical mechanisms and potential therapeutic target

MMJ Chua, CE Ortega, A Sheikh, M Lee… - Pharmaceuticals, 2017 - mdpi.com
CK2 genes are overexpressed in many human cancers, and most often overexpression is
associated with worse prognosis. Site-specific expression in mice leads to cancer …

IL-6 promotes head and neck tumor metastasis by inducing epithelial–mesenchymal transition via the JAK-STAT3-SNAIL signaling pathway

A Yadav, B Kumar, J Datta, TN Teknos, P Kumar - Molecular cancer research, 2011 - AACR
Epithelial–mesenchymal transition (EMT) is a key process in tumor metastatic cascade that
is characterized by the loss of cell–cell junctions and cell polarity, resulting in the acquisition …

Dysregulated molecular networks in head and neck carcinogenesis

AA Molinolo, P Amornphimoltham, CH Squarize… - Oral oncology, 2009 - Elsevier
Multiple genetic and epigenetic events, including the aberrant expression and function of
molecules regulating cell signaling, growth, survival, motility, angiogenesis, and cell cycle …

Polymorphonuclear granulocytes in human head and neck cancer: enhanced inflammatory activity, modulation by cancer cells and expansion in advanced disease

S Trellakis, K Bruderek, CA Dumitru… - … journal of cancer, 2011 - Wiley Online Library
The progression of epithelial cancer is associated with an intense immunological interaction
between the tumor cells and immune cells of the host. However, little is known about the …

The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations

JL Geiger, JR Grandis, JE Bauman - Oral oncology, 2016 - Elsevier
Proteins of the signal transducer and activator of transcription (STAT) family mediate cellular
responses to cytokines and growth factors. Aberrant regulation of the STAT3 oncogene …

The PI 3 K/A kt/m TOR axis in head and neck cancer: functions, aberrations, cross‐talk, and therapies

R Vander Broek, S Mohan, DF Eytan, Z Chen… - Oral …, 2015 - Wiley Online Library
Head and neck squamous cell carcinoma (HNSCC) is one of the most morbid, mortal, and
genetically diverse malignancies. Although HNSCC is heterogeneous in nature, alterations …

Quality of life scores predict survival among patients with head and neck cancer

CA Karvonen-Gutierrez, DL Ronis… - Journal of Clinical …, 2008 - ascopubs.org
Purpose The purpose of this study was to examine whether quality of life (QOL) scores
predict survival among patients with head and neck cancer, controlling for demographic …

Multiplexed immunobead‐based assay for detection of oral cancer protein biomarkers in saliva

ME Arellano‐Garcia, S Hu, J Wang, B Henson… - Oral …, 2008 - Wiley Online Library
Objective: For clinical applications of biomarkers, there is a need for multiplex assays using
high throughput platforms. The objective of this study was to determine the efficacy of …

TRAF3/CYLD mutations identify a distinct subset of human papillomavirus‐associated head and neck squamous cell carcinoma

M Hajek, A Sewell, S Kaech, B Burtness… - Cancer, 2017 - Wiley Online Library
BACKGROUND The incidence of human papillomavirus (HPV)‐associated (HPV‐positive)
head and neck squamous cell carcinoma (HNSCC) of the oropharynx has dramatically …