Epilepsy is a central nervous system disorder involving spontaneous and recurring seizures
that affects 50 million individuals globally. Because approximately one-third of patients with …

The correlation between sleep and epilepsy has been argued over the past decades among
scientists. Although the similarities and contrasts between sleep and epilepsy had been …

Background: Exogenous melatonin is commonly used to treat insomnia, other sleep
problems, and numerous medical illnesses, including Alzheimer's disease, autism spectrum …

Oxidative stress develops when there is an excess of oxidants leading to molecular and
cellular damage. Seizure activity leads to oxidative stress and the resulting increased lipid …

The relationship of sleep and epilepsy demonstrates the delicate association of brain
physiology and dysfunction. Sleep affects the distribution and frequency of epileptiform …

Melatonin is a pleiotropic biofactor and an effective antioxidant and free radical scavenger
and, as such, can be protective in oxidative stress‐related brain conditions including …

Purpose Epilepsy, one severe prevalent brain disorder, primarily relies on drug treatment.
However, approximately one-third of patients with epilepsy do not achieve effective control …

Objective POLR3B encodes the second largest subunit of RNA polymerase III, which is
essential for transcription of small non‐coding RNAs. Biallelic pathogenic variants in …

Abstract The voltage‐gated Kv3. 1/KCNC1 channel is abundantly expressed in fast‐spiking
principal neurons and GABAergic inhibitory interneurons throughout the ascending auditory …

Objective Posttranscriptional mechanisms are increasingly recognized as important
contributors to the formation of hyperexcitable networks in epilepsy. Messenger RNA …