Macrophage polarization states in atherosclerosis

J Wu, S He, Z Song, S Chen, X Lin, H Sun… - Frontiers in …, 2023 - frontiersin.org
Atherosclerosis, a chronic inflammatory condition primarily affecting large and medium
arteries, is the main cause of cardiovascular diseases. Macrophages are key mediators of …

Galectokines: the promiscuous relationship between galectins and cytokines

L Sanjurjo, EC Broekhuizen, RR Koenen… - Biomolecules, 2022 - mdpi.com
Galectins, a family of glycan-binding proteins, are well-known for their role in shaping the
immune microenvironment. They can directly affect the activity and survival of different …

[HTML][HTML] Non-classical circulating monocytes expressing high levels of microsomal prostaglandin E2 synthase-1 tag an aberrant IFN-response in systemic sclerosis

G Villanueva-Martin, M Acosta-Herrera… - Journal of …, 2023 - Elsevier
Systemic sclerosis (SSc) is a complex disease that affects the connective tissue, causing
fibrosis. SSc patients show altered immune cell composition and activation in the peripheral …

Galectin-2 in health and diseases

MN Negedu, CA Duckworth, LG Yu - International Journal of Molecular …, 2022 - mdpi.com
Galectin-2 is a prototype member of the galactoside-binding galectin family. It is
predominately expressed in the gastrointestinal tract but is also detected in several other …

PARP inhibition promotes endothelial‐like traits in melanoma cells and modulates pericyte coverage dynamics during vasculogenic mimicry

M Fernández‐Cortés, D Delgado‐Bellido… - The Journal of …, 2023 - Wiley Online Library
Vasculogenic mimicry (VM) describes the ability of highly aggressive tumor cells to develop
pseudovascular structures without the participation of endothelial cells. PARP1 is implicated …

Galectin functions in cancer-associated inflammation and thrombosis

L Kruk, A Braun, E Cosset, T Gudermann… - Frontiers in …, 2023 - frontiersin.org
Galectins are carbohydrate-binding proteins that regulate many cellular functions including
proliferation, adhesion, migration, and phagocytosis. Increasing experimental and clinical …

Glycosylation of blood cells during the onset and progression of atherosclerosis and myocardial infarction

F Ferro, R Spelat, A Pandit, JL Martin-Ventura… - Trends in Molecular …, 2024 - cell.com
Protein glycosylation controls cell–cell and cell–extracellular matrix (ECM) communication in
immune, vascular, and inflammatory processes, underlining the critical role of this process in …

Single domain antibody: Development and application in biotechnology and biopharma

T Yu, F Zheng, W He, S Muyldermans… - Immunological …, 2024 - Wiley Online Library
Heavy‐chain antibodies (HCAbs) are a unique type of antibodies devoid of light chains, and
comprised of two heavy chains‐only that recognize their cognate antigen by virtue of a …

Evaluation of Plasma Concentrations of Galectins-1, 2 and 12 in Psoriasis and Their Clinical Implications

J Nowowiejska, A Baran, JM Hermanowicz… - Biomolecules, 2023 - mdpi.com
Psoriasis is a complex disease that nowadays is considered not only a dermatosis but a kind
of systemic disorder associated with many accompanying diseases. Metabolic complications …

Galectins and Host–Pathogen Interactions: The roles in viral infections

SF Wang, HL Chen, FT Liu - Seminars in Immunology, 2024 - Elsevier
Galectins, a family of carbohydrate-binding proteins, play crucial roles in the host–virus
interaction landscape. This review explores the multifaceted contributions of endogenous …