Viral and bacterial co-infections in the lungs: dangerous liaisons
Respiratory tract infections constitute a significant public health problem, with a therapeutic
arsenal that remains relatively limited and that is threatened by the emergence of antiviral …
arsenal that remains relatively limited and that is threatened by the emergence of antiviral …
Early-life respiratory syncytial virus disease and long-term respiratory health
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection
(LRTI), hospital admission, and mortality in children worldwide. Early-life RSV LRTI has also …
(LRTI), hospital admission, and mortality in children worldwide. Early-life RSV LRTI has also …
SARS-CoV-2 infection and viral load are associated with the upper respiratory tract microbiome
C Rosas-Salazar, KS Kimura, MH Shilts… - Journal of Allergy and …, 2021 - Elsevier
Background Little is known about the relationships between severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), the respiratory virus responsible for the ongoing …
syndrome coronavirus 2 (SARS-CoV-2), the respiratory virus responsible for the ongoing …
Severe COVID-19 is associated with an altered upper respiratory tract microbiome
MH Shilts, C Rosas-Salazar, BA Strickland… - Frontiers in cellular …, 2022 - frontiersin.org
Background The upper respiratory tract (URT) is the portal of entry of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), and SARS-CoV-2 likely interacts with …
respiratory syndrome coronavirus 2 (SARS-CoV-2), and SARS-CoV-2 likely interacts with …
Mucosal immune responses to respiratory syncytial virus
MVC Barnes, PJM Openshaw, RS Thwaites - Cells, 2022 - mdpi.com
Despite over half a century of research, respiratory syncytial virus (RSV)-induced
bronchiolitis remains a major cause of hospitalisation in infancy, while vaccines and specific …
bronchiolitis remains a major cause of hospitalisation in infancy, while vaccines and specific …
Intracellular proteomics and extracellular vesiculomics as a metric of disease recapitulation in 3D-bioprinted aortic valve arrays
In calcific aortic valve disease (CAVD), mechanosensitive valvular cells respond to fibrosis-
and calcification-induced tissue stiffening, further driving pathophysiology. No …
and calcification-induced tissue stiffening, further driving pathophysiology. No …
[HTML][HTML] Metatranscriptomics to characterize respiratory virome, microbiome, and host response directly from clinical samples
SV Rajagopala, NG Bakhoum, SB Pakala, MH Shilts… - Cell reports …, 2021 - cell.com
We developed a metatranscriptomics method that can simultaneously capture the
respiratory virome, microbiome, and host response directly from low biomass samples …
respiratory virome, microbiome, and host response directly from low biomass samples …
The microbiota/host immune system interaction in the nose to protect from COVID-19
Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and is characterized by variable clinical presentation that …
coronavirus 2 (SARS-CoV-2) and is characterized by variable clinical presentation that …
[HTML][HTML] Microbiome and micronutrient in ALS: From novel mechanisms to new treatments
J Sun, Y Zhang - Neurotherapeutics, 2024 - Elsevier
Amyotrophic lateral sclerosis is a neurodegenerative disorder. Despite extensive studies, it
remains challenging to treat ALS. Recent ALS studies have shown dysbiosis (eg, loss of …
remains challenging to treat ALS. Recent ALS studies have shown dysbiosis (eg, loss of …
Coagulation factors induce human skin mast cell and basophil degranulation via activation of complement 5 and the C5a receptor
Y Yanase, Y Matsuo, S Takahagi… - Journal of Allergy and …, 2021 - jacionline.org
LETTERS TO THE EDITOR 1101 or IIa induced histamine release by themselves, but the
combination of C5 and factor IIa or factor Xa did (Fig 2, B). These results suggest that C5a …
combination of C5 and factor IIa or factor Xa did (Fig 2, B). These results suggest that C5a …