Nature combines existing biochemical building blocks, at times with subtlety of purpose.
RNA modifications are a prime example of this, where standard RNA nucleosides are …

Transfer RNA–guanine transglycosylases (TGTs) are evolutionarily ancient enzymes,
present in all kingdoms of life, catalyzing guanine exchange within their cognate tRNAs by …

The eukaryotic tRNA guanine transglycosylase (TGT) is an RNA modifying enzyme
incorporating queuine, a hypermodified guanine derivative, into the tRNAsAsp, Asn, His, Tyr …

Eukaryotic tRNA guanine transglycosylase (TGT) is an RNA-modifying enzyme which
catalyzes the base exchange of the genetically encoded guanine 34 of tRNAs Asp, Asn, His …

Base-modification can occur throughout a transfer RNA molecule; however, elaboration is
particularly prevalent at position 34 of the anticodon loop (the wobble position), where it …

The bacterial tRNA-guanine transglycosylase (TGT) is a tRNA modifying enzyme catalyzing
the exchange of guanine 34 by the modified base preQ1. The enzyme is involved in the …

Shigella flexneri is an enteropathogen responsible for severe dysentery in humans. VirF is a
key transcriptional regulator that activates the expression of the downstream virulence …

RNA modifications have been implicated in diverse and important roles in all kingdoms of
life with over 100 of them present on tRNAs. A prominent modification at the wobble base of …

The tRNA-modifying enzyme tRNA-guanine transglycosylase (Tgt) is a putative target for
new selective antibiotics against Shigella bacteria. The formation of a Tgt homodimer was …

Queuosine (Q) is a naturally occurring modified nucleoside that occurs in the first position of
transfer RNA anticodons such as Asp, Asn, His, and Tyr. As eukaryotes lack pathways to …