The fertility and survival of an individual rely on the ability of the periphery to promptly,
effectively, and reproducibly communicate with brain neural networks that control …

Anorexia is commonly present in persons with cancer and a major component of cancer
cachexia. There are multiple causes of anorexia in cancer. Peripherally, these can be due to …

The metabolic and energy state of the organism depends largely on the availability of
substrates, such as glucose for ATP production, necessary for maintaining physiological …

Sleep is essential for health. Indeed, poor sleep is consistently linked to the development of
systemic disease, including depression, metabolic syndrome, and cognitive impairments …

Hypothalamic glucose sensing enables an organism to match energy expenditure and food
intake to circulating levels of glucose, the main energy source of the brain. Here, we …

Aim This study aims to review the current evidence regarding appetite problem in cancer
patients, mainly focusing on pathophysiology, diagnosis, and treatment. Introduction …

Previous studies indicate that the activity of hypothalamic POMC neurons can be regulated
by glucose via intracellular mechanisms, but its regulation by lactate is poorly understood. In …

Tanycytes are elongated hypothalamic glial cells that cover the basal walls of the third
ventricle; their apical regions contact the cerebrospinal fluid (CSF), and their processes …

Lactate, a molecule originally considered metabolic waste, is now associated with a number
of important physiological functions. Although the roles of lactate as a signaling molecule …

Vitamin C is an essential micronutrient in the human diet; its deficiency leads to a number of
symptoms and ultimately death. After entry into cells within the central nervous system (CNS) …