Recent advances in the tandem copper-catalyzed Ullmann–Goldberg N-arylation–cyclization strategies

JM Honnanayakanavar, O Obulesu… - Organic & Biomolecular …, 2022 - pubs.rsc.org
N–Aryl bond formation under copper catalysis has played a pivotal role and has been
extensively used as a key step in the total syntheses of several therapeutic molecules. The …

Synthesis of quinazoline and quinazolinone derivatives via ligand-promoted ruthenium-catalyzed dehydrogenative and deaminative coupling reaction of 2 …

PT Kirinde Arachchige, CS Yi - Organic letters, 2019 - ACS Publications
The in situ formed ruthenium catalytic system ([Ru]/L) was found to be highly selective for the
dehydrogenative coupling reaction of 2-aminophenyl ketones with amines to form …

Ru doped hydrotalcite catalyzed borrowing hydrogen-mediated N-alkylation of benzamides, sulfonamides, and dehydrogenative synthesis of quinazolinones

B Sardar, R Jamatia, A Samanta… - The Journal of Organic …, 2022 - ACS Publications
An efficient Ru doped hydrotalcite catalyzed N-alkylation of benzamides and sulfonamides
with alcohols via borrowing hydrogen catalysis is illustrated. Various primary alcohols …

A microwave assisted tandem synthesis of quinazolinones using ionic liquid supported copper (ii) catalyst with mechanistic insights

U Dasmahapatra, B Maiti, K Chanda - Organic & Biomolecular …, 2024 - pubs.rsc.org
Quinazolinone is a preferred structural motif with notable pharmacological activity that is
present in a wide range of naturally occurring compounds. A microwave assisted tandem …

Regioselective Synthesis of 2° Amides Using Visible-Light-Induced Photoredox-Catalyzed Nonaqueous Oxidative C–N Cleavage of N,N-Dibenzylanilines

N Neerathilingam, M Bhargava Reddy… - The Journal of Organic …, 2021 - ACS Publications
A visible-light-driven photoredox-catalyzed nonaqueous oxidative C–N cleavage of N, N-
dibenzylanilines to 2° amides is reported. Further, we have applied this protocol on 2 …

Cobalt-catalyzed tandem transformation of 2-aminobenzonitriles to quinazolinones using hydration and dehydrogenative coupling strategy

SA Samim, BC Roy, S Nayak… - The Journal of Organic …, 2020 - ACS Publications
A tandem synthesis of quinazolinones from 2-aminobenzonitriles is demonstrated here by
using an aliphatic alcohol–water system. For this transformation, a cheap and easily …

Direct diversification of unmasked quinazolin-4 (3 H)-ones through orthogonal reactivity modulation

JB Lee, ME Kang, J Kim, CY Lee, JM Kee… - Chemical …, 2017 - pubs.rsc.org
Here we report a set of direct functionalization methods of unmasked 2-phenylquinazolin-4
(3H)-ones, a privileged alkaloid core, without the installation/removal event of protecting …

Iron-catalyzed one-pot sequential transformations: synthesis of quinazolinones via oxidative Csp3H bond activation using a new metal-organic framework as catalyst

TA To, YH Vo, HTT Nguyen, PTM Ha, SH Doan… - Journal of …, 2019 - Elsevier
A new mixed-linker iron-based MOF VNU-21 [Fe 3 (BTC)(EDB) 2· 12.27 H 2 O] was
synthesized via mixed-linker synthetic strategy using 1, 3, 5-benzenetricarboxylic acid, 4 …

Synthesis of Quinazolin-4(3H)-ones via the Reaction of 2-Halobenzamides with Nitriles

X Yu, L Gao, L Jia, Y Yamamoto… - The Journal of Organic …, 2018 - ACS Publications
This paper describes a convenient method to synthesize quinazolin-4 (3 H)-ones from
simple and readily available 2-halobenzamides and nitriles. The Lewis acid Cu-catalyzed …

Efficient Synthesis of Quinazolinones by Transition‐Metal‐Free Direct Aerobic Oxidative Cascade Annulation of Alcohols with o‐Aminoarylnitriles

Q Wang, M Lv, J Liu, Y Li, Q Xu, X Zhang… - …, 2019 - Wiley Online Library
A mild and atom‐economic method was developed for direct and efficient synthesis of
quinazolinones through a transition‐metal‐free aerobic oxidative cascade annulation …