Familial hypercholesterolaemia is common in individuals who had a myocardial infarction at
a young age. As many as one in 200 people could have heterozygous familial …

Atherosclerotic cardiovascular disease is the leading cause of death globally. Despite its
important risk of premature atherosclerosis and cardiovascular disease, familial …

Material de distribuição exclusiva à classe médica. Os Arquivos Brasileiros de Cardiologia
não se responsabilizam pelo acesso indevido a seu conteúdo e que contrarie a …

Aim Our aim was to assess the efficacy and safety of mipomersen through a systematic
review of the literature and a meta-analysis of the available clinical studies. Methods A …

Cholesterol is a waxy substance found in blood lipids. Its role in the human body is helpful in
the process of producing new cells as long as it is at a healthy level. When cholesterol …

Current evidence indicates that foods with added plant sterols or stanols can lower serum
levels of low-density lipoprotein cholesterol. This review summarizes the recent findings and …

Background and aims Patients with familial hypercholesterolemia (FH) are often
characterized by premature coronary artery disease (CAD) with heterogeneity at onset. The …

The dilemma of how to categorize and classify diseases has been debated for centuries.
The field of medical genetics has historically approached nosology based on clinical …

Financial declaration A-Economically relevant payments of any kind made to (i) you,(ii) your
spouse/partner or any other person living with you,(iii) any legal person in which any of …

Antisense oligonucleotides (ASO), short single-stranded polymers based on DNA or RNA
chemistries and synthesized in vitro, regulate gene expression by binding in a sequence …