Caspase-8: The double-edged sword

R Mandal, JC Barrón, I Kostova, S Becker… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Caspase-8 is a cysteine-aspartate specific protease that classically triggers the extrinsic
apoptotic pathway, in response to the activation of cell surface Death Receptors (DRs) like …

[HTML][HTML] Recent advances in prostate cancer research: Large-scale genomic analyses reveal novel driver mutations and DNA repair defects

S Frank, P Nelson, V Vasioukhin - F1000Research, 2018 - ncbi.nlm.nih.gov
Prostate cancer (PCa) is a disease of mutated and misregulated genes. However, primary
prostate tumors have relatively few mutations, and only three genes (ERG, PTEN, and …

Therapeutic monoclonal antibody targeting of neuronal pentraxin receptor to control metastasis in gastric cancer

M Kanda, D Shimizu, K Sawaki, S Nakamura… - Molecular Cancer, 2020 - Springer
Background Controlling metastasis is essential for improving the prognosis of patients with
gastric cancer (GC). Here, we aimed to identify a molecule required for GC metastasis and to …

SYT7 acts as a driver of hepatic metastasis formation of gastric cancer cells

M Kanda, H Tanaka, D Shimizu, T Miwa, S Umeda… - Oncogene, 2018 - nature.com
Liver metastasis remains a serious problem in the management of gastric cancer (GC). Our
aims were to identify through transcriptome analysis a molecule that mediates hepatic …

Multifunctional carbon dots originated from waste garlic peel for rapid sensing of heavy metals and fluorescent imaging of 2D and 3D spheroids cultured fibroblast …

P Krishnaiah, R Atchudan, S Perumal… - … Acta Part A: Molecular …, 2024 - Elsevier
Here, we prepared sulfur and nitrogen self-doped carbon dots derived from garlic peel
extract (GPSNCDs) using a hydrothermal method. The as-synthesized GPSNCDs were …

Triptolide inhibits CD133+/CD44+ colon cancer stem cell growth and migration through triggering apoptosis and represses epithelial‐mesenchymal transition via …

E Acikgoz, C Tatar, G Oktem - Journal of Cellular Biochemistry, 2020 - Wiley Online Library
High recurrence and metastatic behavior patterns are the most important reasons for the
failure of treatment strategies in patients with colon cancer. Cancer stem cells (CSCs), which …

[HTML][HTML] Knockdown of ZEB1 reverses cancer stem cell properties in prostate cancer cells

G Pérez, F López‑Moncada, S Indo… - Oncology …, 2021 - spandidos-publications.com
Prostate cancer (PCa) is the second most diagnosed type of cancer in men worldwide.
Advanced PCa is resistant to conventional therapies and high recurrence has been …

Adaptive phenotypic modulations lead to therapy resistance in chronic myeloid leukemia cells

S Baykal-Köse, E Acikgoz, AS Yavuz, Ö Gönül Geyik… - PLoS …, 2020 - journals.plos.org
Tyrosine kinase inhibitor (TKI) resistance is a major problem in chronic myeloid leukemia
(CML). We generated a TKI-resistant K562 sub-population, K562-IR, under selective …

Marine power on cancer: Drugs, lead compounds, and mechanisms

L Wu, K Ye, S Jiang, G Zhou - Marine Drugs, 2021 - mdpi.com
Worldwide, 19.3 million new cancer cases and almost 10.0 million cancer deaths occur each
year. Recently, much attention has been paid to the ocean, the largest biosphere of the earth …

[HTML][HTML] Periplocin extracted from cortex periplocae induced apoptosis of gastric cancer cells via the ERK1/2-EGR1 pathway

L Li, LM Zhao, S Dai, WX Cui, HL Lv, L Chen… - Cellular Physiology and …, 2016 - karger.com
Background/Aims: Periplocin is extracted from the traditional herbal medicine cortex
periplocae, which has been reported to suppress the growth of cancer cells. However, little …