Cardiomyopathies and valvular heart diseases are typically considered distinct diagnostic
categories with dedicated guidelines for their management. However, the interplay between …

Background: Over the last five decades, a fair number of echocardiographic studies have
evaluated the prevalence of mitral valve prolapse (MVP) in various cohorts of individuals …

Heart development relies on a topologically defined interplay between a diverse array of
cardiac cells. We finely curated spatial and single-cell measurements with subcellular …

Background Mitral valve prolapse (MVP) is a common cardiac valvular anomaly that can be
caused by mutations in genes of various biological pathways. Individuals of three …

Impaired mitochondria cause an impressive decrease in ATP production becoming a
common condition of cardiovascular diseases. Myxomatous mitral valve disease (MMVD) is …

Degenerative mitral valve disease is a common valvular disease with two arguably distinct
phenotypes: fibroelastic deficiency and Barlow's disease. These phenotypes significantly …

BACKGROUND: Mitral valve (MV) disease including myxomatous degeneration is the most
common form of valvular heart disease with an age-dependent frequency. Genetic evidence …

Background: Mitral valve (MV) disease including myxomatous degeneration is the most
common form of valvular heart disease with an age-dependent frequency. Genetic evidence …

Neural crest cells (NCCs) are a multipotent embryonic cell population of ectodermal origin
that extensively migrate during early development and contribute to the formation of multiple …

Cardiac and vascular valve disease is among the most common cardiovascular disorders in
the United States, with as much as≈ 7% of the population affected. 1 The cardiac valves …