In 1971, Folkman proposed that tumors could be limited to very small sizes by blocking
angiogenesis. Angiogenesis is the generation of new blood vessels from pre-existing …

Notch signaling, an evolutionarily conserved signaling cascade, is critical for normal
biological processes of cell differentiation, development, and homeostasis. Deregulation of …

Emodin, a natural anthraquinone derivative, possesses anti-proliferative and anti-
inflammatory properties in skin diseases. However, little information is available on the …

Emodin is applied as an antitumor drug in many tumor therapies. However, its
pharmacology performances are limited due to its low solubility. Herein, we fused …

The marine ecosystem, populated by a myriad of animals, plants, and microorganisms, is an
inexhaustible reservoir of pharmacologically active molecules. Among the multiple …

The current COVID-19 outbreak has highlighted the need for the development of new
vaccines and drugs to combat Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS …

Abstract Background Iron (Fe)-induced oxidative stress leads to reactive oxygen species that
damage biomembranes, with this mechanism being involved in the activity of some anti …

Infertility is an emerging health issue worldwide, and female infertility is intimately
associated with embryo implantation failure. Embryo implantation is an essential process …

The inadequate vascularization seen in fast-growing solid tumors gives rise to hypoxic
areas, fostering specific changes in gene expression that bolster tumor cell survival and …

Emerging mycotoxins are currently gaining more attention due to their high frequency of
contamination in foods and grains. However, most data available in the literature are in vitro …