[HTML][HTML] Melanin content in melanoma metastases affects the outcome of radiotherapy

AA Brożyna, W Jóźwicki, K Roszkowski, J Filipiak… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Melanin possess radioprotective and scavenging properties, and its presence can affect the
behavior of melanoma cells, its surrounding environment and susceptibility to the therapy …

[HTML][HTML] Benzamide derivative radiotracers targeting melanin for melanoma imaging and therapy: Preclinical/clinical development and combination with other …

J Rouanet, M Quintana, P Auzeloux, F Cachin… - Pharmacology & …, 2021 - Elsevier
Cutaneous melanoma arises from proliferating melanocytes, cells specialized in the
production of melanin. This property means melanin can be considered as a target for …

The roles of cellular nanomechanics in cancer

MM Yallapu, KS Katti, DR Katti… - Medicinal research …, 2015 - Wiley Online Library
The biomechanical properties of cells and tissues may be instrumental in increasing our
understanding of cellular behavior and cellular manifestations of diseases such as cancer …

Melanin presence inhibits melanoma cell spread in mice in a unique mechanical fashion

M Sarna, M Krzykawska-Serda, M Jakubowska… - Scientific reports, 2019 - nature.com
Melanoma is a highly aggressive cancer that exhibits metastasis to various critical organs.
Unlike any other cancer cells, melanoma cells can synthesize melanin in large amounts …

Differentiating melanoma and healthy tissues based on elasticity-specific Brillouin microspectroscopy

M Troyanova-Wood, Z Meng… - Biomedical optics …, 2019 - opg.optica.org
The main objective of the present study is to evaluate the use of Brillouin microspectroscopy
for differentiation of melanoma and normal tissues based on elasticity measurements …

Melatonin exerts oncostatic capacity and decreases melanogenesis in human MNT‐1 melanoma cells

K Kleszczyński, TK Kim, B Bilska… - Journal of pineal …, 2019 - Wiley Online Library
Melanogenesis is a key parameter of differentiation in melanocytes and melanoma cells;
therefore, search for factors regulating this pathway are strongly desired. Herein, we …

Cell elasticity is an important indicator of the metastatic phenotype of melanoma cells

M Sarna, A Zadlo, P Hermanowicz… - Experimental …, 2014 - Wiley Online Library
The relationship between melanin pigmentation and metastatic phenotype of melanoma
cells is an intricate issue, which needs to be unambiguously determined to fully understand …

Melanoma in the Eyes of Mechanobiology

MM Brás, M Radmacher, SR Sousa… - Frontiers in cell and …, 2020 - frontiersin.org
Skin is the largest organ of the human body with several important functions that can be
impaired by injury, genetic or chronic diseases. Among all skin diseases, melanoma is one …

Nanomechanical phenotype of melanoma cells depends solely on the amount of endogenous pigment in the cells

M Sarna, A Zadlo, B Czuba-Pelech… - International journal of …, 2018 - mdpi.com
Cancer cells have unique nanomechanical properties, ie, they behave as if they were
elastic. This property of cancer cells is believed to be one of the main reasons for their …

Lipofuscin-mediated photodynamic stress induces adverse changes in nanomechanical properties of retinal pigment epithelium cells

A Wiktor, M Sarna, D Wnuk, T Sarna - Scientific reports, 2018 - nature.com
Retinal pigment epithelium (RPE) is an important part of the blood-retina barrier (BRB) that
separates the retina from the choroid. Although melanin granules contribute to the …