Cell migration is fundamental to establishing and maintaining the proper organization of
multicellular organisms. Morphogenesis can be viewed as a consequence, in part, of cell …

Mucus is a complex biological material that lubricates and protects the human lungs,
gastrointestinal (GI) tract, vagina, eyes, and other moist mucosal surfaces. Mucus serves as …

The recovery of an intact epithelium following lung injury is critical for restoration of lung
homeostasis. The initial processes following injury include an acute inflammatory response …

Cell migration on 2D surfaces is governed by a balance between counteracting tractile and
adhesion forces. Although biochemical factors such as adhesion receptor and ligand …

Aging is a complex, multifaceted process that induces a myriad of physiological changes
over an extended period of time. Aging is accompanied by major biochemical and …

Focal adhesions are large multi-protein assemblies that form at the basal surface of cells on
planar dishes, and that mediate cell signalling, force transduction and adhesion to the …

A multitude of cellular and subcellular processes depend critically on the mechanical
deformability of the cytoplasm. We have recently introduced the method of particle-tracking …

It is now widely appreciated that normal tissue morphology and function rely upon cells'
ability to sense and generate forces appropriate to their correct tissue context. Although the …

Single-cell analysis is essential to improve our understanding of cell functionality from
cellular and subcellular aspects for diagnosis and therapy. Single-cell cultivation is one of …

Lamin A/C is a major constituent of the nuclear lamina, a thin filamentous protein layer that
lies beneath the nuclear envelope. Here we show that lamin A/C deficiency in mouse …