The cell–cell connections in adherens junctions (AJs) are mediated by transmembrane
receptors, type I cadherins (referred to here as cadherins). These cadherin-based …

Embryonic development is a dynamic process orchestrated by a delicate interplay of
biochemical and biophysical factors. While the role of genetics and biochemistry in …

The cortical actin cytoskeleton plays a critical role in maintaining intestinal epithelial
integrity, and the loss of this architecture leads to chronic inflammation, as seen in …

Animal organs exhibit complex topologies involving cavities and tubular networks, which
underlie their form and function,–. However, how topology emerges during the development …

EPH/EPHRIN signaling is essential to many aspects of tissue self-organization and
morphogenesis, but little is known about how EPH/EPHRIN signaling regulates cell …

To fulfil their function, epithelial tissues need to sustain mechanical stresses and avoid
rupture. Although rupture is usually undesired, it is central to some developmental …

Metazoan development relies on the formation and remodeling of cell-cell contacts.
Dynamic reorganization of adhesion receptors and the actomyosin cell cortex in space and …

细胞膜是细胞与外部环境进行物质与能量交换的界面, 是调节细胞正常生命活动的重要结构基础
. 细胞膜上力敏感受体可通过力学作用方式参与并影响细胞的力信号转导等功能 …

Multicellular systems, such as epithelial cell collectives, undergo transitions similar to those
in inert physical systems like sand piles and foams. To remodel or maintain tissue …

Intercellular adhesion is the key to multicellularity, and its malfunction plays an important
role in various developmental and disease-related processes. Although it has been …