Best practices for analysing microbiomes

R Knight, A Vrbanac, BC Taylor, A Aksenov… - Nature Reviews …, 2018 - nature.com
Complex microbial communities shape the dynamics of various environments, ranging from
the mammalian gastrointestinal tract to the soil. Advances in DNA sequencing technologies …

Correlation and association analyses in microbiome study integrating multiomics in health and disease

Y Xia - Progress in molecular biology and translational …, 2020 - Elsevier
Correlation and association analyses are one of the most widely used statistical methods in
research fields, including microbiome and integrative multiomics studies. Correlation and …

NetCoMi: network construction and comparison for microbiome data in R

S Peschel, CL Müller, E Von Mutius… - Briefings in …, 2021 - academic.oup.com
Motivation Estimating microbial association networks from high-throughput sequencing data
is a common exploratory data analysis approach aiming at understanding the complex …

An introduction to next generation sequencing bioinformatic analysis in gut microbiome studies

B Gao, L Chi, Y Zhu, X Shi, P Tu, B Li, J Yin, N Gao… - Biomolecules, 2021 - mdpi.com
The gut microbiome is a microbial ecosystem which expresses 100 times more genes than
the human host and plays an essential role in human health and disease pathogenesis …

Metatranscriptome of human faecal microbial communities in a cohort of adult men

GS Abu-Ali, RS Mehta, J Lloyd-Price, H Mallick… - Nature …, 2018 - nature.com
The gut microbiome is intimately related to human health, but it is not yet known which
functional activities are driven by specific microorganisms' ecological configurations or …

Candida expansion in the gut of lung cancer patients associates with an ecological signature that supports growth under dysbiotic conditions

B Seelbinder, Z Lohinai, R Vazquez-Uribe… - Nature …, 2023 - nature.com
Candida species overgrowth in the human gut is considered a prerequisite for invasive
candidiasis, but our understanding of gut bacteria promoting or restricting this overgrowth is …

Chromosomally normal miscarriage is associated with vaginal dysbiosis and local inflammation

K Grewal, YS Lee, A Smith, JJ Brosens, T Bourne… - BMC medicine, 2022 - Springer
Background Emerging evidence supports an association between vaginal microbiota
composition and risk of miscarriage; however, the underlying mechanisms are poorly …

Antibiotics create a shift from mutualism to competition in human gut communities with a longer-lasting impact on fungi than bacteria

B Seelbinder, J Chen, S Brunke, R Vazquez-Uribe… - Microbiome, 2020 - Springer
Background Antibiotic treatment has a well-established detrimental effect on the gut
bacterial composition, but effects on the fungal community are less clear. Bacteria in the …

Effect of tectonic processes on biosphere–geosphere feedbacks across a convergent margin

KM Fullerton, MO Schrenk, M Yücel, E Manini… - Nature …, 2021 - nature.com
The subsurface is among Earth's largest biomes, but the extent to which microbial
communities vary across tectonic plate boundaries or interact with subduction-scale …

A statistical model for describing and simulating microbial community profiles

S Ma, B Ren, H Mallick, YS Moon… - PLoS computational …, 2021 - journals.plos.org
Many methods have been developed for statistical analysis of microbial community profiles,
but due to the complex nature of typical microbiome measurements (eg sparsity, zero …