Telomeres are the physical ends of eukaryotic linear chromosomes. Telomeres form special
structures that cap chromosome ends to prevent degradation by nucleolytic attack and to …

All living organisms are continuously faced with endogenous or exogenous stress
conditions affecting genome stability. DNA repair pathways act as a defense mechanism …

Abstract Replication Protein A (RPA) is a broadly conserved complex comprised of the
RPA1, 2 and 3 subunits. RPA protects the exposed single-stranded DNA (ssDNA) during …

For nearly all eukaryotic cells, stochastic DNA double-strand breaks (DSBs) are one of the
most deleterious types of DNA lesions. DSB processing and repair can cause sequence …

Trypanosomatids are the etiologic agents of various infectious diseases in humans. They
diverged early during eukaryotic evolution and have attracted attention as peculiar models …

In trypanosomatids, etiological agents of devastating diseases, replication is robust and
finely controlled to maintain genome stability and function in stressful environments …

Leishmaniasis is a spectrum of diseases caused by parasites of the genus Leishmania that
affects millions of people around the world. During infection, the parasites use different …

Here, we show the morphological events associated with organelle segregation and their
timing in the cell cycle of a reference strain of Leishmania (L.) amazonensis promastigotes …

Telomeres from different eukaryotes, including trypanosomatids, are transcribed into TERRA
noncoding RNAs, crucial in regulating chromatin deposition and telomere length. TERRA is …

Telomere maintenance is essential for genome integrity and chromosome stability in
eukaryotic cells harboring linear chromosomes, as telomere forms a specialized structure to …