While red blood cell (RBC) transfusion is the most common medical intervention in
hospitalized patients, as with any therapeutic, it is not without risk. Allogeneic RBC exposure …

Blood transfusion is the most common procedure completed during a given hospitalization
in the United States. Although often life-saving, transfusions are not risk-free. One sequela …

Transfusions can be a life-saving treatment of patients with sickle-cell disease (SCD).
However, availability of matched units can be limiting because of distinctive blood group …

Red cell transfusion remains a critical component of care for acute and chronic
complications of sickle cell disease. Randomized clinical trials demonstrated the benefits of …

A hemolytic transfusion reaction (HTR) is the accelerated clearance or destruction of red
blood cells associated with a transfusion event. Causes of HTRs and differential diagnoses …

Red blood cell (RBC) transfusions can result in alloimmunization toward RBC alloantigens
that can increase the probability of complications following subsequent transfusion. An …

Patients with sickle cell disease (SCD) often receive red blood cell (RBC) transfusion
support for the prevention and management of many acute and chronic disease …

Erythrocyte alloimmunization is a major barrier to transfusion in sickle cell disease (SCD)
because it can lead to transfusion deadlock and the development of life-threatening …

Transfusion of red blood cells (RBC) remains a primary treatment modality in patients with
sickle cell disease (SCD). Repeated exposure to alloantigens on transfused RBCs can lead …

Alloimmunization against red blood cell antigens and delayed hemolytic transfusion reaction
(DHTR) are major barriers to transfusion in sickle cell disease (SCD). In SCD, DHTR is a …